node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C3 | C4BPA | ENSCPOP00000018087 | ENSCPOP00000003880 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | C4bp alpha-chain. | 0.811 |
C3 | C4BPB | ENSCPOP00000018087 | ENSCPOP00000000333 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Complement component 4 binding protein beta. | 0.760 |
C3 | C5 | ENSCPOP00000018087 | ENSCPOP00000002041 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Complement C5. | 0.935 |
C3 | CD19 | ENSCPOP00000018087 | ENSCPOP00000001807 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | B-lymphocyte antigen CD19; Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in [...] | 0.431 |
C3 | Cfi | ENSCPOP00000018087 | ENSCPOP00000003800 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Uncharacterized protein; Belongs to the peptidase S1 family. | 0.971 |
C3 | H0W7A0_CAVPO | ENSCPOP00000018087 | ENSCPOP00000018854 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | NTR domain-containing protein. | 0.536 |
C3 | LOC100721435 | ENSCPOP00000018087 | ENSCPOP00000012574 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. | 0.573 |
C3 | ZP3R | ENSCPOP00000018087 | ENSCPOP00000005657 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Zona pellucida sperm-binding protein 3 receptor; Probably involved in the formation of the dense core and M1 domain of the acrosome. May also regulate the release of certain secretory proteins following the acrosomal reaction. | 0.804 |
C4BPA | C3 | ENSCPOP00000003880 | ENSCPOP00000018087 | C4bp alpha-chain. | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | 0.811 |
C4BPA | C4BPB | ENSCPOP00000003880 | ENSCPOP00000000333 | C4bp alpha-chain. | Complement component 4 binding protein beta. | 0.890 |
C4BPA | C5 | ENSCPOP00000003880 | ENSCPOP00000002041 | C4bp alpha-chain. | Complement C5. | 0.719 |
C4BPA | CD19 | ENSCPOP00000003880 | ENSCPOP00000001807 | C4bp alpha-chain. | B-lymphocyte antigen CD19; Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in [...] | 0.680 |
C4BPA | Cfi | ENSCPOP00000003880 | ENSCPOP00000003800 | C4bp alpha-chain. | Uncharacterized protein; Belongs to the peptidase S1 family. | 0.700 |
C4BPA | FGG | ENSCPOP00000003880 | ENSCPOP00000007313 | C4bp alpha-chain. | Fibrinogen gamma chain. | 0.678 |
C4BPA | H0W7A0_CAVPO | ENSCPOP00000003880 | ENSCPOP00000018854 | C4bp alpha-chain. | NTR domain-containing protein. | 0.755 |
C4BPA | LOC100721435 | ENSCPOP00000003880 | ENSCPOP00000012574 | C4bp alpha-chain. | Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. | 0.689 |
C4BPA | LOC100728345 | ENSCPOP00000003880 | ENSCPOP00000022343 | C4bp alpha-chain. | Anaphylatoxin-like domain-containing protein. | 0.811 |
C4BPA | ZP3R | ENSCPOP00000003880 | ENSCPOP00000005657 | C4bp alpha-chain. | Zona pellucida sperm-binding protein 3 receptor; Probably involved in the formation of the dense core and M1 domain of the acrosome. May also regulate the release of certain secretory proteins following the acrosomal reaction. | 0.700 |
C4BPB | C3 | ENSCPOP00000000333 | ENSCPOP00000018087 | Complement component 4 binding protein beta. | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | 0.760 |
C4BPB | C4BPA | ENSCPOP00000000333 | ENSCPOP00000003880 | Complement component 4 binding protein beta. | C4bp alpha-chain. | 0.890 |