EPOR protein (Cavia porcellus) - STRING interaction network

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Score

EPOR

Erythropoietin receptor. (540 aa)

Predicted Functional Partners:

EPO

0.999

JAK2

0.997

JAK3

0.977

JAK1

0.953

TFR2

0.947

TYK2

0.942

TFRC

0.917

GRB2

0.902

Thpo

0.898

PIK3R1

0.874

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EPO	EPOR	ENSCPOP00000016307	ENSCPOP00000004407	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Erythropoietin receptor.	0.999
EPO	GRB2	ENSCPOP00000016307	ENSCPOP00000031642	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Growth factor receptor bound protein 2.	0.527
EPO	JAK1	ENSCPOP00000016307	ENSCPOP00000005409	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Tyrosine-protein kinase.	0.790
EPO	JAK2	ENSCPOP00000016307	ENSCPOP00000013203	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Tyrosine-protein kinase.	0.890
EPO	JAK3	ENSCPOP00000016307	ENSCPOP00000026323	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Tyrosine-protein kinase.	0.790
EPO	PIK3R1	ENSCPOP00000016307	ENSCPOP00000007043	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Phosphoinositide-3-kinase regulatory subunit 1.	0.437
EPO	TFRC	ENSCPOP00000016307	ENSCPOP00000026959	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Transferrin receptor protein 1.	0.492
EPO	TYK2	ENSCPOP00000016307	ENSCPOP00000003938	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Tyrosine-protein kinase.	0.708
EPO	Thpo	ENSCPOP00000016307	ENSCPOP00000023605	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Uncharacterized protein.	0.894
EPOR	EPO	ENSCPOP00000004407	ENSCPOP00000016307	Erythropoietin receptor.	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	0.999
EPOR	GRB2	ENSCPOP00000004407	ENSCPOP00000031642	Erythropoietin receptor.	Growth factor receptor bound protein 2.	0.902
EPOR	JAK1	ENSCPOP00000004407	ENSCPOP00000005409	Erythropoietin receptor.	Tyrosine-protein kinase.	0.953
EPOR	JAK2	ENSCPOP00000004407	ENSCPOP00000013203	Erythropoietin receptor.	Tyrosine-protein kinase.	0.997
EPOR	JAK3	ENSCPOP00000004407	ENSCPOP00000026323	Erythropoietin receptor.	Tyrosine-protein kinase.	0.977
EPOR	PIK3R1	ENSCPOP00000004407	ENSCPOP00000007043	Erythropoietin receptor.	Phosphoinositide-3-kinase regulatory subunit 1.	0.874
EPOR	TFR2	ENSCPOP00000004407	ENSCPOP00000010036	Erythropoietin receptor.	Transferrin receptor 2.	0.947
EPOR	TFRC	ENSCPOP00000004407	ENSCPOP00000026959	Erythropoietin receptor.	Transferrin receptor protein 1.	0.917
EPOR	TYK2	ENSCPOP00000004407	ENSCPOP00000003938	Erythropoietin receptor.	Tyrosine-protein kinase.	0.942
EPOR	Thpo	ENSCPOP00000004407	ENSCPOP00000023605	Erythropoietin receptor.	Uncharacterized protein.	0.898
GRB2	EPO	ENSCPOP00000031642	ENSCPOP00000016307	Growth factor receptor bound protein 2.	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	0.527