STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLF1SMC5-SMC6 complex localization factor 1. (1061 aa)    
Predicted Functional Partners:
ATR
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 0.998
BARD1
BRCA1 associated RING domain 1.
   
0.998
BRIP1
BRCA1 interacting protein C-terminal helicase 1.
  
 0.996
NBN
Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.
    
 0.996
Rtel1
Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]
  
 0.996
CDC45
Cell division cycle 45.
   
 
 0.995
PSMD12
Proteasome 26S subunit, non-ATPase 12.
    
 0.995
RAD17
RAD17 checkpoint clamp loader component.
  
 0.993
WRN
WRN RecQ like helicase.
  
 0.993
ATRIP
ATR interacting protein.
    
 0.992
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.