BRCA2 protein (Cavia porcellus) - STRING interaction network

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[Homology]

Score

BRCA2

BRCA2 DNA repair associated. (3151 aa)

Predicted Functional Partners:

FANCD2

0.999

PALB2

0.999

Brca1

0.999

RAD51

0.999

RAD51C

0.998

BARD1

0.998

XRCC3

0.997

Sem1

0.995

BRIP1

0.992

TP53

0.991

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARD1	BRCA2	ENSCPOP00000010340	ENSCPOP00000004635	BRCA1 associated RING domain 1.	BRCA2 DNA repair associated.	0.998
BARD1	BRIP1	ENSCPOP00000010340	ENSCPOP00000010475	BRCA1 associated RING domain 1.	BRCA1 interacting protein C-terminal helicase 1.	0.995
BARD1	Brca1	ENSCPOP00000010340	ENSCPOP00000012252	BRCA1 associated RING domain 1.	Uncharacterized protein.	0.999
BARD1	FANCD2	ENSCPOP00000010340	ENSCPOP00000005156	BRCA1 associated RING domain 1.	FA complementation group D2.	0.915
BARD1	PALB2	ENSCPOP00000010340	ENSCPOP00000006213	BRCA1 associated RING domain 1.	Partner and localizer of BRCA2.	0.964
BARD1	RAD51	ENSCPOP00000010340	ENSCPOP00000012705	BRCA1 associated RING domain 1.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.996
BARD1	RAD51C	ENSCPOP00000010340	ENSCPOP00000004133	BRCA1 associated RING domain 1.	RAD51 paralog C.	0.939
BARD1	TP53	ENSCPOP00000010340	ENSCPOP00000029751	BRCA1 associated RING domain 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.990
BARD1	XRCC3	ENSCPOP00000010340	ENSCPOP00000015766	BRCA1 associated RING domain 1.	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	0.870
BRCA2	BARD1	ENSCPOP00000004635	ENSCPOP00000010340	BRCA2 DNA repair associated.	BRCA1 associated RING domain 1.	0.998
BRCA2	BRIP1	ENSCPOP00000004635	ENSCPOP00000010475	BRCA2 DNA repair associated.	BRCA1 interacting protein C-terminal helicase 1.	0.992
BRCA2	Brca1	ENSCPOP00000004635	ENSCPOP00000012252	BRCA2 DNA repair associated.	Uncharacterized protein.	0.999
BRCA2	FANCD2	ENSCPOP00000004635	ENSCPOP00000005156	BRCA2 DNA repair associated.	FA complementation group D2.	0.999
BRCA2	PALB2	ENSCPOP00000004635	ENSCPOP00000006213	BRCA2 DNA repair associated.	Partner and localizer of BRCA2.	0.999
BRCA2	RAD51	ENSCPOP00000004635	ENSCPOP00000012705	BRCA2 DNA repair associated.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.999
BRCA2	RAD51C	ENSCPOP00000004635	ENSCPOP00000004133	BRCA2 DNA repair associated.	RAD51 paralog C.	0.998
BRCA2	Sem1	ENSCPOP00000004635	ENSCPOP00000027210	BRCA2 DNA repair associated.	Uncharacterized protein.	0.995
BRCA2	TP53	ENSCPOP00000004635	ENSCPOP00000029751	BRCA2 DNA repair associated.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.991
BRCA2	XRCC3	ENSCPOP00000004635	ENSCPOP00000015766	BRCA2 DNA repair associated.	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	0.997
BRIP1	BARD1	ENSCPOP00000010475	ENSCPOP00000010340	BRCA1 interacting protein C-terminal helicase 1.	BRCA1 associated RING domain 1.	0.995