Shc4 protein (Cavia porcellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

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experimentally determined

co-expression

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gene neighborhood

gene co-occurrence

gene fusions

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[Homology]

Score

Shc4

Uncharacterized protein. (372 aa)

Predicted Functional Partners:

GRB2

0.962

EGFR

0.957

ERBB2

0.957

ERBB4

0.957

ERBB3

0.957

FGFR3

0.946

PDGFRB

0.937

FGFR1

0.937

HCK

0.937

KDR

0.937

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ERBB2	ENSCPOP00000000034	ENSCPOP00000005210	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.998
EGFR	ERBB3	ENSCPOP00000000034	ENSCPOP00000013382	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.997
EGFR	ERBB4	ENSCPOP00000000034	ENSCPOP00000010099	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.982
EGFR	FGFR1	ENSCPOP00000000034	ENSCPOP00000005900	Receptor protein-tyrosine kinase.	Fibroblast growth factor receptor.	0.495
EGFR	FGFR3	ENSCPOP00000000034	ENSCPOP00000026305	Receptor protein-tyrosine kinase.	Fibroblast growth factor receptor.	0.759
EGFR	GRB2	ENSCPOP00000000034	ENSCPOP00000031642	Receptor protein-tyrosine kinase.	Growth factor receptor bound protein 2.	0.999
EGFR	HCK	ENSCPOP00000000034	ENSCPOP00000007076	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.914
EGFR	KDR	ENSCPOP00000000034	ENSCPOP00000008975	Receptor protein-tyrosine kinase.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.625
EGFR	PDGFRB	ENSCPOP00000000034	ENSCPOP00000005411	Receptor protein-tyrosine kinase.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.991
EGFR	Shc4	ENSCPOP00000000034	ENSCPOP00000005877	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.957
ERBB2	EGFR	ENSCPOP00000005210	ENSCPOP00000000034	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.998
ERBB2	ERBB3	ENSCPOP00000005210	ENSCPOP00000013382	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.999
ERBB2	ERBB4	ENSCPOP00000005210	ENSCPOP00000010099	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.999
ERBB2	FGFR1	ENSCPOP00000005210	ENSCPOP00000005900	Receptor protein-tyrosine kinase.	Fibroblast growth factor receptor.	0.882
ERBB2	FGFR3	ENSCPOP00000005210	ENSCPOP00000026305	Receptor protein-tyrosine kinase.	Fibroblast growth factor receptor.	0.937
ERBB2	GRB2	ENSCPOP00000005210	ENSCPOP00000031642	Receptor protein-tyrosine kinase.	Growth factor receptor bound protein 2.	0.999
ERBB2	HCK	ENSCPOP00000005210	ENSCPOP00000007076	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.699
ERBB2	KDR	ENSCPOP00000005210	ENSCPOP00000008975	Receptor protein-tyrosine kinase.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.622
ERBB2	PDGFRB	ENSCPOP00000005210	ENSCPOP00000005411	Receptor protein-tyrosine kinase.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.955
ERBB2	Shc4	ENSCPOP00000005210	ENSCPOP00000005877	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.957