NPHS1 protein (Cavia porcellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

NPHS1

NPHS1 adhesion molecule, nephrin. (1252 aa)

Predicted Functional Partners:

KIRREL1

0.980

KIRREL3

0.979

KIRREL2

0.970

CD2AP

0.930

NCK1

0.877

NCK2

0.866

TJP1

0.854

NPHS2

0.843

FYN

0.824

SH3KBP1

0.817

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD2AP	FYN	ENSCPOP00000009657	ENSCPOP00000025358	CD2 associated protein.	Tyrosine-protein kinase.	0.601
CD2AP	KIRREL1	ENSCPOP00000009657	ENSCPOP00000021820	CD2 associated protein.	Kirre like nephrin family adhesion molecule 1.	0.717
CD2AP	KIRREL2	ENSCPOP00000009657	ENSCPOP00000006031	CD2 associated protein.	Kirre like nephrin family adhesion molecule 2.	0.419
CD2AP	KIRREL3	ENSCPOP00000009657	ENSCPOP00000029300	CD2 associated protein.	Kirre like nephrin family adhesion molecule 3.	0.679
CD2AP	NCK1	ENSCPOP00000009657	ENSCPOP00000022728	CD2 associated protein.	Cytoplasmic protein.	0.480
CD2AP	NPHS1	ENSCPOP00000009657	ENSCPOP00000006022	CD2 associated protein.	NPHS1 adhesion molecule, nephrin.	0.930
CD2AP	NPHS2	ENSCPOP00000009657	ENSCPOP00000031729	CD2 associated protein.	NPHS2 stomatin family member, podocin.	0.775
CD2AP	SH3KBP1	ENSCPOP00000009657	ENSCPOP00000005796	CD2 associated protein.	SH3 domain containing kinase binding protein 1.	0.804
CD2AP	TJP1	ENSCPOP00000009657	ENSCPOP00000009819	CD2 associated protein.	Tight junction protein 1; Belongs to the MAGUK family.	0.701
FYN	CD2AP	ENSCPOP00000025358	ENSCPOP00000009657	Tyrosine-protein kinase.	CD2 associated protein.	0.601
FYN	KIRREL1	ENSCPOP00000025358	ENSCPOP00000021820	Tyrosine-protein kinase.	Kirre like nephrin family adhesion molecule 1.	0.618
FYN	KIRREL2	ENSCPOP00000025358	ENSCPOP00000006031	Tyrosine-protein kinase.	Kirre like nephrin family adhesion molecule 2.	0.550
FYN	KIRREL3	ENSCPOP00000025358	ENSCPOP00000029300	Tyrosine-protein kinase.	Kirre like nephrin family adhesion molecule 3.	0.580
FYN	NCK1	ENSCPOP00000025358	ENSCPOP00000022728	Tyrosine-protein kinase.	Cytoplasmic protein.	0.811
FYN	NCK2	ENSCPOP00000025358	ENSCPOP00000014330	Tyrosine-protein kinase.	Cytoplasmic protein.	0.616
FYN	NPHS1	ENSCPOP00000025358	ENSCPOP00000006022	Tyrosine-protein kinase.	NPHS1 adhesion molecule, nephrin.	0.824
FYN	SH3KBP1	ENSCPOP00000025358	ENSCPOP00000005796	Tyrosine-protein kinase.	SH3 domain containing kinase binding protein 1.	0.562
FYN	TJP1	ENSCPOP00000025358	ENSCPOP00000009819	Tyrosine-protein kinase.	Tight junction protein 1; Belongs to the MAGUK family.	0.526
KIRREL1	CD2AP	ENSCPOP00000021820	ENSCPOP00000009657	Kirre like nephrin family adhesion molecule 1.	CD2 associated protein.	0.717
KIRREL1	FYN	ENSCPOP00000021820	ENSCPOP00000025358	Kirre like nephrin family adhesion molecule 1.	Tyrosine-protein kinase.	0.618

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.862

expected number of edges:

19

PPI enrichment p-value:

0.537

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006749

Glutathione metabolic process

5 of 39

2.4

3.79

3.56e-08

GO:0006518

Peptide metabolic process

9 of 433

1.61

3.01

2.69e-10

GO:0006572

Tyrosine catabolic process

3 of 6

2.99

2.72

1.13e-05

GO:0006559

L-phenylalanine catabolic process

3 of 9

2.81

2.51

2.54e-05

GO:0006412

Translation

5 of 333

1.47

1.46

0.00020

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004364

Glutathione transferase activity

4 of 16

2.69

3.38

4.76e-07

GO:0003746

Translation elongation factor activity

4 of 24

2.51

3.16

1.00e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005853

Eukaryotic translation elongation factor 1 complex

2 of 2

3.29

1.52

0.0018

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3977

Eukaryotic Translation Elongation, and Translation release factor complex

4 of 6

3.11

4.07

3.70e-08

CL:1155

Tyrosine catabolism, and 4-hydroxyphenylpyruvate dioxygenase

3 of 5

3.07

2.69

1.32e-05

CL:2389

Glutathione S-transferase, C-terminal domain, and Epoxide metabolic process

3 of 10

2.77

2.37

4.49e-05

CL:2393

Glutathione S-transferase, N-terminal domain

2 of 5

2.89

1.61

0.0012

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tru00982

Drug metabolism - cytochrome P450

3 of 35

2.22

2.0

0.00014

tru00980

Metabolism of xenobiotics by cytochrome P450

3 of 36

2.21

2.0

0.00014

tru00983

Drug metabolism - other enzymes

3 of 57

2.01

1.87

0.00018

tru00480

Glutathione metabolism

3 of 56

2.02

1.87

0.00018

tru01100

Metabolic pathways

5 of 1393

0.84

0.56

0.0130

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-156842

Eukaryotic Translation Elongation

4 of 7

3.05

4.19

2.06e-08

MAP-156590

Glutathione conjugation

4 of 27

2.46

3.14

9.79e-07

MAP-8963684

Tyrosine catabolism

3 of 6

2.99

2.92

4.68e-06

MAP-8963691

Phenylalanine and tyrosine metabolism

3 of 18

2.51

2.33

4.43e-05

MAP-156580

Phase II - Conjugation of compounds

4 of 76

2.01

2.24

2.43e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005853

Eukaryotic translation elongation factor 1 complex

3 of 3

3.29

3.05

3.05e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0251

Elongation factor

4 of 11

2.85

4.18

1.71e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF14497

Glutathione S-transferase, C-terminal domain

5 of 9

3.03

5.55

5.70e-11

PF02798

Glutathione S-transferase, N-terminal domain

4 of 9

2.94

4.07

3.11e-08

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036282

Glutathione S-transferase, C-terminal domain superfamily

6 of 28

2.62

5.44

2.82e-11

IPR004046

Glutathione S-transferase, C-terminal

4 of 12

2.81

3.61

2.09e-07

IPR004045

Glutathione S-transferase, N-terminal

4 of 15

2.71

3.5

2.96e-07

IPR010987

Glutathione S-transferase, C-terminal-like

4 of 20

2.59

3.3

6.08e-07

IPR036219

Translation elongation factor eEF-1beta-like superfamily

3 of 4

3.16

2.96

4.30e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01182

Eukaryotic elongation factor 1 beta central acidic region

3 of 4

3.16

3.07

2.74e-06

SM00888

EF-1 guanine nucleotide exchange domain

3 of 4

3.16

3.07

2.74e-06

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