node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADM | CALCR | ENSCPOP00000022366 | ENSCPOP00000006261 | Adrenomedullin. | Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. | 0.989 |
ADM | Calcb | ENSCPOP00000022366 | ENSCPOP00000022273 | Adrenomedullin. | CALCITONIN domain-containing protein. | 0.941 |
ADM | GNG2 | ENSCPOP00000022366 | ENSCPOP00000024690 | Adrenomedullin. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.670 |
ADM | H0VE70_CAVPO | ENSCPOP00000022366 | ENSCPOP00000008303 | Adrenomedullin. | Uncharacterized protein. | 0.678 |
ADM | H0VFQ8_CAVPO | ENSCPOP00000022366 | ENSCPOP00000008918 | Adrenomedullin. | CALCITONIN domain-containing protein. | 0.805 |
ADM | IAPP | ENSCPOP00000022366 | ENSCPOP00000008717 | Adrenomedullin. | Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family. | 0.937 |
ADM | LOC100732436 | ENSCPOP00000022366 | ENSCPOP00000031430 | Adrenomedullin. | Uncharacterized protein. | 0.680 |
ADM | RAMP1 | ENSCPOP00000022366 | ENSCPOP00000020178 | Adrenomedullin. | Receptor activity-modifying protein 1; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL (By similarity). | 0.982 |
ADM | RAMP2 | ENSCPOP00000022366 | ENSCPOP00000029954 | Adrenomedullin. | Receptor activity-modifying protein 2; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (By similarity). | 0.997 |
ADM | RAMP3 | ENSCPOP00000022366 | ENSCPOP00000012027 | Adrenomedullin. | Receptor activity-modifying protein 3; Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (By similarity). | 0.992 |
CALCR | ADM | ENSCPOP00000006261 | ENSCPOP00000022366 | Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. | Adrenomedullin. | 0.989 |
CALCR | Calcb | ENSCPOP00000006261 | ENSCPOP00000022273 | Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. | CALCITONIN domain-containing protein. | 0.973 |
CALCR | GNG2 | ENSCPOP00000006261 | ENSCPOP00000024690 | Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.937 |
CALCR | H0VE70_CAVPO | ENSCPOP00000006261 | ENSCPOP00000008303 | Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. | Uncharacterized protein. | 0.951 |
CALCR | H0VFQ8_CAVPO | ENSCPOP00000006261 | ENSCPOP00000008918 | Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. | CALCITONIN domain-containing protein. | 0.911 |
CALCR | IAPP | ENSCPOP00000006261 | ENSCPOP00000008717 | Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. | Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family. | 0.990 |
CALCR | LOC100732436 | ENSCPOP00000006261 | ENSCPOP00000031430 | Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. | Uncharacterized protein. | 0.953 |
CALCR | RAMP1 | ENSCPOP00000006261 | ENSCPOP00000020178 | Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. | Receptor activity-modifying protein 1; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL (By similarity). | 0.993 |
CALCR | RAMP2 | ENSCPOP00000006261 | ENSCPOP00000029954 | Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. | Receptor activity-modifying protein 2; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (By similarity). | 0.988 |
CALCR | RAMP3 | ENSCPOP00000006261 | ENSCPOP00000012027 | Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. | Receptor activity-modifying protein 3; Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (By similarity). | 0.994 |