UFL1 protein (Cavia porcellus) - STRING interaction network

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Score

UFL1

UFM1 specific ligase 1. (762 aa)

Predicted Functional Partners:

CDK5RAP3

0.963

DDRGK1

0.960

UBA5

0.838

UFC1

0.804

UFM1

0.756

ATG7

0.676

UBA3

0.671

UEVLD

0.645

UFSP2

0.621

MOCS3

0.582

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG7	MOCS3	ENSCPOP00000023655	ENSCPOP00000014289	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...]	0.554
ATG7	UBA3	ENSCPOP00000023655	ENSCPOP00000029198	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Ubiquitin like modifier activating enzyme 3.	0.845
ATG7	UBA5	ENSCPOP00000023655	ENSCPOP00000008909	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Ubiquitin like modifier activating enzyme 5.	0.814
ATG7	UFC1	ENSCPOP00000023655	ENSCPOP00000017242	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.	0.619
ATG7	UFL1	ENSCPOP00000023655	ENSCPOP00000006275	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	UFM1 specific ligase 1.	0.676
ATG7	UFM1	ENSCPOP00000023655	ENSCPOP00000027981	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes.	0.693
CDK5RAP3	DDRGK1	ENSCPOP00000006554	ENSCPOP00000001152	CDK5 regulatory subunit associated protein 3.	DDRGK domain containing 1.	0.973
CDK5RAP3	UBA5	ENSCPOP00000006554	ENSCPOP00000008909	CDK5 regulatory subunit associated protein 3.	Ubiquitin like modifier activating enzyme 5.	0.553
CDK5RAP3	UFC1	ENSCPOP00000006554	ENSCPOP00000017242	CDK5 regulatory subunit associated protein 3.	Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.	0.644
CDK5RAP3	UFL1	ENSCPOP00000006554	ENSCPOP00000006275	CDK5 regulatory subunit associated protein 3.	UFM1 specific ligase 1.	0.963
CDK5RAP3	UFM1	ENSCPOP00000006554	ENSCPOP00000027981	CDK5 regulatory subunit associated protein 3.	Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes.	0.488
CDK5RAP3	UFSP2	ENSCPOP00000006554	ENSCPOP00000009097	CDK5 regulatory subunit associated protein 3.	UFM1 specific peptidase 2.	0.578
DDRGK1	CDK5RAP3	ENSCPOP00000001152	ENSCPOP00000006554	DDRGK domain containing 1.	CDK5 regulatory subunit associated protein 3.	0.973
DDRGK1	UBA5	ENSCPOP00000001152	ENSCPOP00000008909	DDRGK domain containing 1.	Ubiquitin like modifier activating enzyme 5.	0.560
DDRGK1	UFC1	ENSCPOP00000001152	ENSCPOP00000017242	DDRGK domain containing 1.	Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.	0.802
DDRGK1	UFL1	ENSCPOP00000001152	ENSCPOP00000006275	DDRGK domain containing 1.	UFM1 specific ligase 1.	0.960
DDRGK1	UFM1	ENSCPOP00000001152	ENSCPOP00000027981	DDRGK domain containing 1.	Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes.	0.736
DDRGK1	UFSP2	ENSCPOP00000001152	ENSCPOP00000009097	DDRGK domain containing 1.	UFM1 specific peptidase 2.	0.646
MOCS3	ATG7	ENSCPOP00000014289	ENSCPOP00000023655	Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...]	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.554
MOCS3	UBA3	ENSCPOP00000014289	ENSCPOP00000029198	Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...]	Ubiquitin like modifier activating enzyme 3.	0.585