STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)    
Predicted Functional Partners:
IL2RA
Interleukin 2 receptor subunit alpha.
    
 0.998
IL2RB
Interleukin 2 receptor subunit beta.
    
 0.998
Il2rg
Fibronectin type-III domain-containing protein.
    
 0.997
Il4
Interleukin-4.
   
 
 0.991
IL7
Interleukin 7.
     
 0.986
IL5
Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.
   
 
 0.962
CSF3
Colony stimulating factor 3.
   
 
 0.960
FOXP3
Forkhead box P3.
   
 0.946
IL15
Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family.
     
 0.923
IL13
Interleukin 13.
   
 
 0.919
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.