node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADSS2 | APRT | ENSCPOP00000002128 | ENSCPOP00000018935 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Adenine phosphoribosyltransferase. | 0.808 |
ADSS2 | ATIC | ENSCPOP00000002128 | ENSCPOP00000011522 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | 0.986 |
ADSS2 | CNNM1 | ENSCPOP00000002128 | ENSCPOP00000007750 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Cyclin and CBS domain divalent metal cation transport mediator 1. | 0.586 |
ADSS2 | GMPS | ENSCPOP00000002128 | ENSCPOP00000010411 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Guanine monophosphate synthase. | 0.641 |
ADSS2 | HPRT1 | ENSCPOP00000002128 | ENSCPOP00000002288 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.914 |
ADSS2 | ITPA | ENSCPOP00000002128 | ENSCPOP00000023761 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.926 |
ADSS2 | NT5E | ENSCPOP00000002128 | ENSCPOP00000000989 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.865 |
APRT | ADSS2 | ENSCPOP00000018935 | ENSCPOP00000002128 | Adenine phosphoribosyltransferase. | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.808 |
APRT | ATIC | ENSCPOP00000018935 | ENSCPOP00000011522 | Adenine phosphoribosyltransferase. | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | 0.985 |
APRT | CNNM1 | ENSCPOP00000018935 | ENSCPOP00000007750 | Adenine phosphoribosyltransferase. | Cyclin and CBS domain divalent metal cation transport mediator 1. | 0.617 |
APRT | GMPS | ENSCPOP00000018935 | ENSCPOP00000010411 | Adenine phosphoribosyltransferase. | Guanine monophosphate synthase. | 0.995 |
APRT | HPRT1 | ENSCPOP00000018935 | ENSCPOP00000002288 | Adenine phosphoribosyltransferase. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.932 |
APRT | ITPA | ENSCPOP00000018935 | ENSCPOP00000023761 | Adenine phosphoribosyltransferase. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.926 |
APRT | NT5E | ENSCPOP00000018935 | ENSCPOP00000000989 | Adenine phosphoribosyltransferase. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.965 |
ATIC | ADSS2 | ENSCPOP00000011522 | ENSCPOP00000002128 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.986 |
ATIC | APRT | ENSCPOP00000011522 | ENSCPOP00000018935 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | Adenine phosphoribosyltransferase. | 0.985 |
ATIC | CNNM1 | ENSCPOP00000011522 | ENSCPOP00000007750 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | Cyclin and CBS domain divalent metal cation transport mediator 1. | 0.798 |
ATIC | GMPS | ENSCPOP00000011522 | ENSCPOP00000010411 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | Guanine monophosphate synthase. | 0.865 |
ATIC | HPRT1 | ENSCPOP00000011522 | ENSCPOP00000002288 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.928 |
ATIC | ITPA | ENSCPOP00000011522 | ENSCPOP00000023761 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.917 |