CCL5 protein (Cavia porcellus) - STRING interaction network

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CCL5

C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)

Predicted Functional Partners:

CCL17

0.999

CXCL10

0.999

CXCL9

0.998

CCL27

0.998

CXCL12

0.998

CXCL11

0.997

CCL21

0.996

CCR3

0.996

Ccl25

0.994

LOC100732171

0.994

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL17	CCL21	ENSCPOP00000005702	ENSCPOP00000004888	C-C motif chemokine.	C-C motif chemokine ligand 21.	0.990
CCL17	CCL27	ENSCPOP00000005702	ENSCPOP00000022422	C-C motif chemokine.	C-C motif chemokine ligand 27.	0.788
CCL17	CCL5	ENSCPOP00000005702	ENSCPOP00000007949	C-C motif chemokine.	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	0.999
CCL17	CCR3	ENSCPOP00000005702	ENSCPOP00000016457	C-C motif chemokine.	C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1.	0.919
CCL17	CXCL10	ENSCPOP00000005702	ENSCPOP00000023256	C-C motif chemokine.	C-X-C motif chemokine ligand 10.	0.770
CCL17	CXCL11	ENSCPOP00000005702	ENSCPOP00000026948	C-C motif chemokine.	C-X-C motif chemokine.	0.677
CCL17	CXCL12	ENSCPOP00000005702	ENSCPOP00000022617	C-C motif chemokine.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.739
CCL17	CXCL9	ENSCPOP00000005702	ENSCPOP00000022028	C-C motif chemokine.	C-X-C motif chemokine.	0.735
CCL17	Ccl25	ENSCPOP00000005702	ENSCPOP00000006430	C-C motif chemokine.	SCY domain-containing protein.	0.994
CCL17	LOC100732171	ENSCPOP00000005702	ENSCPOP00000031699	C-C motif chemokine.	C-X-C motif chemokine.	0.550
CCL21	CCL17	ENSCPOP00000004888	ENSCPOP00000005702	C-C motif chemokine ligand 21.	C-C motif chemokine.	0.990
CCL21	CCL27	ENSCPOP00000004888	ENSCPOP00000022422	C-C motif chemokine ligand 21.	C-C motif chemokine ligand 27.	0.839
CCL21	CCL5	ENSCPOP00000004888	ENSCPOP00000007949	C-C motif chemokine ligand 21.	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	0.996
CCL21	CCR3	ENSCPOP00000004888	ENSCPOP00000016457	C-C motif chemokine ligand 21.	C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1.	0.851
CCL21	CXCL10	ENSCPOP00000004888	ENSCPOP00000023256	C-C motif chemokine ligand 21.	C-X-C motif chemokine ligand 10.	0.996
CCL21	CXCL11	ENSCPOP00000004888	ENSCPOP00000026948	C-C motif chemokine ligand 21.	C-X-C motif chemokine.	0.995
CCL21	CXCL12	ENSCPOP00000004888	ENSCPOP00000022617	C-C motif chemokine ligand 21.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.998
CCL21	CXCL9	ENSCPOP00000004888	ENSCPOP00000022028	C-C motif chemokine ligand 21.	C-X-C motif chemokine.	0.996
CCL21	Ccl25	ENSCPOP00000004888	ENSCPOP00000006430	C-C motif chemokine ligand 21.	SCY domain-containing protein.	0.810
CCL21	LOC100732171	ENSCPOP00000004888	ENSCPOP00000031699	C-C motif chemokine ligand 21.	C-X-C motif chemokine.	0.992

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