Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATM | DYRK4 | ENSCPOP00000009885 | ENSCPOP00000009160 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Dual specificity tyrosine phosphorylation regulated kinase 4; Belongs to the protein kinase superfamily. | 0.673 |
| ATM | KCTD2 | ENSCPOP00000009885 | ENSCPOP00000014814 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Potassium channel tetramerization domain containing 2. | 0.632 |
| ATM | MDM2 | ENSCPOP00000009885 | ENSCPOP00000021523 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.940 |
| ATM | MDM4 | ENSCPOP00000009885 | ENSCPOP00000007397 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.873 |
| ATM | SUMO1 | ENSCPOP00000009885 | ENSCPOP00000027854 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Small ubiquitin-related modifier. | 0.669 |
| ATM | TP53 | ENSCPOP00000009885 | ENSCPOP00000029751 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.997 |
| ATM | UBE2I | ENSCPOP00000009885 | ENSCPOP00000030951 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.676 |
| DCAF7 | DYRK4 | ENSCPOP00000023760 | ENSCPOP00000009160 | DDB1 and CUL4 associated factor 7. | Dual specificity tyrosine phosphorylation regulated kinase 4; Belongs to the protein kinase superfamily. | 0.794 |
| DYRK4 | ATM | ENSCPOP00000009160 | ENSCPOP00000009885 | Dual specificity tyrosine phosphorylation regulated kinase 4; Belongs to the protein kinase superfamily. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.673 |
| DYRK4 | DCAF7 | ENSCPOP00000009160 | ENSCPOP00000023760 | Dual specificity tyrosine phosphorylation regulated kinase 4; Belongs to the protein kinase superfamily. | DDB1 and CUL4 associated factor 7. | 0.794 |
| DYRK4 | KCTD2 | ENSCPOP00000009160 | ENSCPOP00000014814 | Dual specificity tyrosine phosphorylation regulated kinase 4; Belongs to the protein kinase superfamily. | Potassium channel tetramerization domain containing 2. | 0.583 |
| DYRK4 | LIN52 | ENSCPOP00000009160 | ENSCPOP00000002870 | Dual specificity tyrosine phosphorylation regulated kinase 4; Belongs to the protein kinase superfamily. | Lin-52 DREAM MuvB core complex component. | 0.602 |
| DYRK4 | MDM2 | ENSCPOP00000009160 | ENSCPOP00000021523 | Dual specificity tyrosine phosphorylation regulated kinase 4; Belongs to the protein kinase superfamily. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.576 |
| DYRK4 | MDM4 | ENSCPOP00000009160 | ENSCPOP00000007397 | Dual specificity tyrosine phosphorylation regulated kinase 4; Belongs to the protein kinase superfamily. | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.680 |
| DYRK4 | PIN1 | ENSCPOP00000009160 | ENSCPOP00000025754 | Dual specificity tyrosine phosphorylation regulated kinase 4; Belongs to the protein kinase superfamily. | Peptidyl-prolyl cis-trans isomerase. | 0.620 |
| DYRK4 | SUMO1 | ENSCPOP00000009160 | ENSCPOP00000027854 | Dual specificity tyrosine phosphorylation regulated kinase 4; Belongs to the protein kinase superfamily. | Small ubiquitin-related modifier. | 0.622 |
| DYRK4 | TP53 | ENSCPOP00000009160 | ENSCPOP00000029751 | Dual specificity tyrosine phosphorylation regulated kinase 4; Belongs to the protein kinase superfamily. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.759 |
| DYRK4 | UBE2I | ENSCPOP00000009160 | ENSCPOP00000030951 | Dual specificity tyrosine phosphorylation regulated kinase 4; Belongs to the protein kinase superfamily. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.583 |
| KCTD2 | ATM | ENSCPOP00000014814 | ENSCPOP00000009885 | Potassium channel tetramerization domain containing 2. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.632 |
| KCTD2 | DYRK4 | ENSCPOP00000014814 | ENSCPOP00000009160 | Potassium channel tetramerization domain containing 2. | Dual specificity tyrosine phosphorylation regulated kinase 4; Belongs to the protein kinase superfamily. | 0.583 |
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