STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TNFRSF21TNF receptor superfamily member 21. (630 aa)    
Predicted Functional Partners:
APP
Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]
    
 
 0.952
APLP2
Amyloid beta precursor like protein 2.
    
 
 0.770
TRADD
TNFRSF1A associated via death domain.
    
 
 0.761
APLP1
Amyloid beta precursor like protein 1.
    
 
 0.658
PODXL2
Podocalyxin like 2.
    
 
 0.613
WFDC13
WAP four-disulfide core domain 13.
    
 
 0.583
HHIP
Hedgehog interacting protein.
    
 
 0.583
CASP6
Caspase 6; Belongs to the peptidase C14A family.
      
 0.532
RTN4RL1
Reticulon 4 receptor like 1.
      
 0.455
IL13RA2
Interleukin 13 receptor subunit alpha 2.
      
 0.444
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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