STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NDRG1N-myc downstream regulated 1. (394 aa)    
Predicted Functional Partners:
NDRG2
NDRG family member 2.
  
 
  
0.668
MYCN
MYCN proto-oncogene, bHLH transcription factor.
    
 
 0.627
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
    
 0.575
Ptma
Uncharacterized protein.
      
 0.574
SERPINF2
Serpin family F member 2; Belongs to the serpin family.
   
  
 0.574
SGK3
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 
 0.572
VASH1
Vasohibin 1.
      
 0.551
NDRG4
NDRG family member 4.
  
 
  
0.547
APOA2
Apolipoprotein A2.
    
 
 0.497
SLC7A5
Solute carrier family 7 member 5.
   
 
 0.470
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.