node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IFNAR1 | IFNG | ENSCPOP00000009203 | ENSCPOP00000009919 | Interferon alpha and beta receptor subunit 1. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | 0.967 |
IFNAR1 | IFNGR1 | ENSCPOP00000009203 | ENSCPOP00000011670 | Interferon alpha and beta receptor subunit 1. | Interferon gamma receptor 1. | 0.976 |
IFNAR1 | IFNGR2 | ENSCPOP00000009203 | ENSCPOP00000008341 | Interferon alpha and beta receptor subunit 1. | Interferon gamma receptor 2. | 0.947 |
IFNAR1 | IL10 | ENSCPOP00000009203 | ENSCPOP00000033012 | Interferon alpha and beta receptor subunit 1. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.954 |
IFNAR1 | IL15 | ENSCPOP00000009203 | ENSCPOP00000007401 | Interferon alpha and beta receptor subunit 1. | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. | 0.853 |
IFNAR1 | IL2RA | ENSCPOP00000009203 | ENSCPOP00000005118 | Interferon alpha and beta receptor subunit 1. | Interleukin 2 receptor subunit alpha. | 0.911 |
IFNAR1 | Ifnar2 | ENSCPOP00000009203 | ENSCPOP00000032478 | Interferon alpha and beta receptor subunit 1. | Uncharacterized protein. | 0.998 |
IFNAR1 | Ifnb1 | ENSCPOP00000009203 | ENSCPOP00000008736 | Interferon alpha and beta receptor subunit 1. | Uncharacterized protein. | 0.990 |
IFNAR1 | JAK1 | ENSCPOP00000009203 | ENSCPOP00000005409 | Interferon alpha and beta receptor subunit 1. | Tyrosine-protein kinase. | 0.988 |
IFNAR1 | JAK2 | ENSCPOP00000009203 | ENSCPOP00000013203 | Interferon alpha and beta receptor subunit 1. | Tyrosine-protein kinase. | 0.960 |
IFNG | IFNAR1 | ENSCPOP00000009919 | ENSCPOP00000009203 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Interferon alpha and beta receptor subunit 1. | 0.967 |
IFNG | IFNGR1 | ENSCPOP00000009919 | ENSCPOP00000011670 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Interferon gamma receptor 1. | 0.999 |
IFNG | IFNGR2 | ENSCPOP00000009919 | ENSCPOP00000008341 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Interferon gamma receptor 2. | 0.996 |
IFNG | IL10 | ENSCPOP00000009919 | ENSCPOP00000033012 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.965 |
IFNG | IL15 | ENSCPOP00000009919 | ENSCPOP00000007401 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. | 0.947 |
IFNG | IL2RA | ENSCPOP00000009919 | ENSCPOP00000005118 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Interleukin 2 receptor subunit alpha. | 0.927 |
IFNG | Ifnar2 | ENSCPOP00000009919 | ENSCPOP00000032478 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Uncharacterized protein. | 0.962 |
IFNG | Ifnb1 | ENSCPOP00000009919 | ENSCPOP00000008736 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Uncharacterized protein. | 0.937 |
IFNG | JAK1 | ENSCPOP00000009919 | ENSCPOP00000005409 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Tyrosine-protein kinase. | 0.927 |
IFNG | JAK2 | ENSCPOP00000009919 | ENSCPOP00000013203 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Tyrosine-protein kinase. | 0.971 |