STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ECE1Endothelin-converting enzyme 1; Converts big endothelin-1 to endothelin-1; Belongs to the peptidase M13 family. (771 aa)    
Predicted Functional Partners:
EDN1
Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.
     
 0.888
EDN3
Endothelin 3.
     
 0.841
FRAS1
Fraser extracellular matrix complex subunit 1.
     
 0.702
AGT
Angiotensinogen; Belongs to the serpin family.
    
 0.650
EDNRB
Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.
      
 0.616
IDE
Insulin degrading enzyme; Belongs to the peptidase M16 family.
      
 0.575
EDNRA
Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.
      
 0.554
ACE
Angiotensin-converting enzyme.
     
 0.529
TLL1
Metalloendopeptidase.
     
 0.522
ACE2
Angiotensin-converting enzyme.
     
 0.521
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.