ACRBP protein (Cavia porcellus) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

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Score

ACRBP

Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin. (543 aa)

Predicted Functional Partners:

TREML1

0.696

GP9

0.695

TUBB1

0.694

SPACA3

0.608

ACR

0.568

PKDREJ

0.525

PCSK4

0.510

PRDX5

0.508

ZPBP2

0.499

DPY19L2

0.495

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACR	ACRBP	ENSCPOP00000008078	ENSCPOP00000011063	Acrosin; Belongs to the peptidase S1 family.	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	0.568
ACR	GP9	ENSCPOP00000008078	ENSCPOP00000017432	Acrosin; Belongs to the peptidase S1 family.	Glycoprotein IX platelet.	0.444
ACR	PCSK4	ENSCPOP00000008078	ENSCPOP00000008110	Acrosin; Belongs to the peptidase S1 family.	Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family.	0.410
ACR	SPACA3	ENSCPOP00000008078	ENSCPOP00000016556	Acrosin; Belongs to the peptidase S1 family.	Sperm acrosome associated 3; Belongs to the glycosyl hydrolase 22 family.	0.478
ACR	ZPBP2	ENSCPOP00000008078	ENSCPOP00000021345	Acrosin; Belongs to the peptidase S1 family.	Zona pellucida binding protein 2.	0.424
ACRBP	ACR	ENSCPOP00000011063	ENSCPOP00000008078	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Acrosin; Belongs to the peptidase S1 family.	0.568
ACRBP	DPY19L2	ENSCPOP00000011063	ENSCPOP00000003454	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Dpy-19 like 2.	0.495
ACRBP	GP9	ENSCPOP00000011063	ENSCPOP00000017432	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Glycoprotein IX platelet.	0.695
ACRBP	PCSK4	ENSCPOP00000011063	ENSCPOP00000008110	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family.	0.510
ACRBP	PKDREJ	ENSCPOP00000011063	ENSCPOP00000018336	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Polycystin family receptor for egg jelly.	0.525
ACRBP	PRDX5	ENSCPOP00000011063	ENSCPOP00000016009	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily.	0.508
ACRBP	SPACA3	ENSCPOP00000011063	ENSCPOP00000016556	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Sperm acrosome associated 3; Belongs to the glycosyl hydrolase 22 family.	0.608
ACRBP	TREML1	ENSCPOP00000011063	ENSCPOP00000003710	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Triggering receptor expressed on myeloid cells like 1.	0.696
ACRBP	TUBB1	ENSCPOP00000011063	ENSCPOP00000030165	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.694
ACRBP	ZPBP2	ENSCPOP00000011063	ENSCPOP00000021345	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Zona pellucida binding protein 2.	0.499
DPY19L2	ACRBP	ENSCPOP00000003454	ENSCPOP00000011063	Dpy-19 like 2.	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	0.495
DPY19L2	ZPBP2	ENSCPOP00000003454	ENSCPOP00000021345	Dpy-19 like 2.	Zona pellucida binding protein 2.	0.483
GP9	ACR	ENSCPOP00000017432	ENSCPOP00000008078	Glycoprotein IX platelet.	Acrosin; Belongs to the peptidase S1 family.	0.444
GP9	ACRBP	ENSCPOP00000017432	ENSCPOP00000011063	Glycoprotein IX platelet.	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	0.695
GP9	TREML1	ENSCPOP00000017432	ENSCPOP00000003710	Glycoprotein IX platelet.	Triggering receptor expressed on myeloid cells like 1.	0.697

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

148

PPI enrichment p-value:

0.633

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006633

Fatty acid biosynthetic process

8 of 68

1.92

4.25

1.36e-11

GO:0019752

Carboxylic acid metabolic process

9 of 566

1.05

1.24

4.41e-07

GO:0044249

Cellular biosynthetic process

9 of 1106

0.76

0.68

0.00010

GO:1901576

Organic substance biosynthetic process

9 of 1134

0.75

0.67

0.00012

GO:0044238

Primary metabolic process

10 of 2411

0.47

0.36

0.0052

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031177

Phosphopantetheine binding

8 of 27

2.32

6.41

9.88e-15

GO:0004315

3-oxoacyl-[acyl-carrier-protein] synthase activity

8 of 28

2.31

6.37

9.88e-15

GO:0019842

Vitamin binding

9 of 101

1.8

4.31

1.23e-13

GO:0003824

Catalytic activity

11 of 3751

0.32

0.25

0.0258

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1386

Phosphopantetheine binding, and Condensation domain

9 of 27

2.37

7.5

2.99e-17

CL:1389

Phosphopantetheine binding, and Condensation domain

7 of 21

2.37

6.07

1.58e-13

CL:1366

Mixed, incl. Phosphopantetheine, and Fatty acid biosynthesis

10 of 132

1.73

4.23

7.68e-15

CL:1391

Phosphopantetheine binding

4 of 12

2.37

3.25

4.69e-07

CL:1418

Erythronolide synthase docking domain, and Phosphopantetheine attachment site

2 of 5

2.45

1.29

0.0043

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00660

C5-Branched dibasic acid metabolism

2 of 16

1.95

0.74

0.0405

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034081

Polyketide synthase complex

8 of 26

2.34

6.65

3.01e-15

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0596

Phosphopantetheine

9 of 54

2.07

5.9

1.03e-15

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16197

Ketoacyl-synthetase C-terminal extension

4 of 6

2.67

3.42

3.96e-07

PF00550

Phosphopantetheine attachment site

5 of 33

2.03

2.98

4.18e-07

PF02801

Beta-ketoacyl synthase, C-terminal domain

3 of 6

2.55

2.3

5.14e-05

PF00109

Beta-ketoacyl synthase, N-terminal domain

3 of 11

2.29

1.98

0.00017

PF14765

Polyketide synthase dehydratase

2 of 2

2.85

1.51

0.0018

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00827

Acyl transferase domain in polyketide synthase (PKS) enzymes.

6 of 10

2.63

5.97

2.19e-12

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

6 of 10

2.63

5.97

2.19e-12

SM00823

Phosphopantetheine attachment site

4 of 13

2.34

3.31

3.12e-07

SM00825

Beta-ketoacyl synthase

3 of 6

2.55

2.71

8.08e-06

SM00826

PKS_DH

2 of 6

2.37

1.46

0.0019

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