STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BRS3Bombesin receptor subtype-3; Role in sperm cell division, maturation, or function. The relative order of ligand affinity is GRP = neuromedin-C >> neuromedin- B. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (399 aa)    
Predicted Functional Partners:
NMB
Neuromedin B.
    
 0.971
GRP
Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family.
     
 0.960
NMBR
Neuromedin B receptor; Belongs to the G-protein coupled receptor 1 family.
     
0.916
GRPR
Gastrin releasing peptide receptor; Belongs to the G-protein coupled receptor 1 family.
     
0.915
Gna15
Uncharacterized protein.
    
  0.764
CCK
Cholecystokinin.
    
 0.751
SEC11C
Signal peptidase complex catalytic subunit SEC11.
     
 0.746
SEC11A
Signal peptidase complex catalytic subunit SEC11.
     
 0.746
NTS
Neurotensin.
    
 0.741
AGT
Angiotensinogen; Belongs to the serpin family.
    
 0.718
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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