STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IL23AInterleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...] (189 aa)    
Predicted Functional Partners:
IL12RB1
Interleukin 12 receptor subunit beta 1.
    
 0.981
TYK2
Tyrosine-protein kinase.
     
 0.914
JAK2
Tyrosine-protein kinase.
     
 0.913
Il4
Interleukin-4.
     
 0.850
IL4R
Interleukin 4 receptor.
  
  
 0.849
IFNGR2
Interferon gamma receptor 2.
  
  
 0.831
IL22RA1
Interleukin 22 receptor subunit alpha 1.
  
  
 0.830
IL10RA
Interleukin 10 receptor subunit alpha.
  
  
 0.826
IL20RA
Interleukin 20 receptor subunit alpha.
  
  
  0.826
IL13RA1
Interleukin 13 receptor subunit alpha 1.
  
  
  0.824
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.