SLC45A1 protein (Cavia porcellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

SLC45A1

Solute carrier family 45 member 1. (700 aa)

Predicted Functional Partners:

SLC16A8

0.564

ANAPC1

0.554

HABP4

0.450

PSD2

0.441

PSMB2

0.441

CCNQ

0.438

VWA7

0.437

SLC24A5

0.437

NOC4L

0.437

DPY19L4

0.436

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANAPC1	PSD2	ENSCPOP00000029085	ENSCPOP00000000134	Anaphase promoting complex subunit 1.	Pleckstrin and Sec7 domain containing 2.	0.420
ANAPC1	SLC45A1	ENSCPOP00000029085	ENSCPOP00000013509	Anaphase promoting complex subunit 1.	Solute carrier family 45 member 1.	0.554
CCNQ	DPY19L4	ENSCPOP00000008305	ENSCPOP00000017514	Cyclin Q; Belongs to the cyclin family.	Dpy-19 like 4.	0.476
CCNQ	HABP4	ENSCPOP00000008305	ENSCPOP00000002257	Cyclin Q; Belongs to the cyclin family.	Hyaluronan binding protein 4.	0.453
CCNQ	NOC4L	ENSCPOP00000008305	ENSCPOP00000020096	Cyclin Q; Belongs to the cyclin family.	Nucleolar complex associated 4 homolog.	0.501
CCNQ	SLC45A1	ENSCPOP00000008305	ENSCPOP00000013509	Cyclin Q; Belongs to the cyclin family.	Solute carrier family 45 member 1.	0.438
CCNQ	VWA7	ENSCPOP00000008305	ENSCPOP00000000782	Cyclin Q; Belongs to the cyclin family.	Von Willebrand factor A domain containing 7.	0.501
DPY19L4	CCNQ	ENSCPOP00000017514	ENSCPOP00000008305	Dpy-19 like 4.	Cyclin Q; Belongs to the cyclin family.	0.476
DPY19L4	HABP4	ENSCPOP00000017514	ENSCPOP00000002257	Dpy-19 like 4.	Hyaluronan binding protein 4.	0.437
DPY19L4	NOC4L	ENSCPOP00000017514	ENSCPOP00000020096	Dpy-19 like 4.	Nucleolar complex associated 4 homolog.	0.438
DPY19L4	SLC45A1	ENSCPOP00000017514	ENSCPOP00000013509	Dpy-19 like 4.	Solute carrier family 45 member 1.	0.436
DPY19L4	VWA7	ENSCPOP00000017514	ENSCPOP00000000782	Dpy-19 like 4.	Von Willebrand factor A domain containing 7.	0.438
HABP4	CCNQ	ENSCPOP00000002257	ENSCPOP00000008305	Hyaluronan binding protein 4.	Cyclin Q; Belongs to the cyclin family.	0.453
HABP4	DPY19L4	ENSCPOP00000002257	ENSCPOP00000017514	Hyaluronan binding protein 4.	Dpy-19 like 4.	0.437
HABP4	NOC4L	ENSCPOP00000002257	ENSCPOP00000020096	Hyaluronan binding protein 4.	Nucleolar complex associated 4 homolog.	0.442
HABP4	SLC45A1	ENSCPOP00000002257	ENSCPOP00000013509	Hyaluronan binding protein 4.	Solute carrier family 45 member 1.	0.450
HABP4	VWA7	ENSCPOP00000002257	ENSCPOP00000000782	Hyaluronan binding protein 4.	Von Willebrand factor A domain containing 7.	0.438
NOC4L	CCNQ	ENSCPOP00000020096	ENSCPOP00000008305	Nucleolar complex associated 4 homolog.	Cyclin Q; Belongs to the cyclin family.	0.501
NOC4L	DPY19L4	ENSCPOP00000020096	ENSCPOP00000017514	Nucleolar complex associated 4 homolog.	Dpy-19 like 4.	0.438
NOC4L	HABP4	ENSCPOP00000020096	ENSCPOP00000002257	Nucleolar complex associated 4 homolog.	Hyaluronan binding protein 4.	0.442

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

22

PPI enrichment p-value:

2.18e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 487

1.63

3.71

1.87e-14

GO:0000027

Ribosomal large subunit assembly

3 of 26

2.33

1.87

0.00029

GO:2000435

Negative regulation of protein neddylation

2 of 5

2.87

1.37

0.0033

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

11 of 295

1.84

5.22

2.17e-17

GO:1990948

Ubiquitin ligase inhibitor activity

2 of 8

2.67

1.04

0.0130

GO:0019843

rRNA binding

3 of 85

1.82

0.96

0.0130

GO:0008097

5S rRNA binding

2 of 16

2.37

0.9

0.0221

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005761

Mitochondrial ribosome

8 of 90

2.22

6.08

1.36e-14

GO:0005762

Mitochondrial large ribosomal subunit

7 of 62

2.33

5.87

2.75e-13

GO:0044391

Ribosomal subunit

11 of 286

1.86

5.37

7.90e-18

GO:0015934

Large ribosomal subunit

9 of 181

1.97

5.21

1.23e-14

GO:0098798

Mitochondrial protein-containing complex

8 of 335

1.65

3.18

1.63e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5581

Organellar large ribosomal subunit, and Mitochondrial translational elongation

8 of 11

3.13

10.22

7.02e-20

CL:5583

Mixed, incl. Mitochondrial translational elongation, and Small ribosomal subunit rRNA binding

3 of 5

3.05

3.02

3.19e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ccan03010

Ribosome

11 of 137

2.18

8.1

5.95e-22

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5419276

Mitochondrial translation termination

8 of 99

2.18

5.75

5.63e-14

MAP-5389840

Mitochondrial translation elongation

8 of 100

2.18

5.73

5.63e-14

MAP-5368287

Mitochondrial translation

8 of 106

2.15

5.66

5.63e-14

MAP-72766

Translation

11 of 463

1.65

3.96

1.45e-15

MAP-392499

Metabolism of proteins

11 of 2639

0.89

1.0

5.33e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005761

Mitochondrial ribosome

8 of 93

2.21

5.94

2.65e-14

GOCC:0005762

Mitochondrial large ribosomal subunit

7 of 59

2.35

5.92

2.63e-13

GOCC:0005840

Ribosome

11 of 277

1.87

5.46

6.37e-18

GOCC:0044391

Ribosomal subunit

10 of 219

1.93

5.45

2.49e-16

GOCC:0015934

Large ribosomal subunit

8 of 124

2.08

5.32

1.44e-13

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

11 of 285

1.86

5.49

1.85e-18

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