node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGO1 | AGO2 | ENSCPOP00000027610 | ENSCPOP00000032420 | Argonaute RISC component 1; Belongs to the argonaute family. | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | 0.985 |
AGO1 | DGCR8 | ENSCPOP00000027610 | ENSCPOP00000028717 | Argonaute RISC component 1; Belongs to the argonaute family. | DGCR8 microprocessor complex subunit. | 0.624 |
AGO1 | DROSHA | ENSCPOP00000027610 | ENSCPOP00000013567 | Argonaute RISC component 1; Belongs to the argonaute family. | Drosha ribonuclease III. | 0.953 |
AGO1 | TARBP2 | ENSCPOP00000027610 | ENSCPOP00000030982 | Argonaute RISC component 1; Belongs to the argonaute family. | RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] | 0.925 |
AGO2 | AGO1 | ENSCPOP00000032420 | ENSCPOP00000027610 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Argonaute RISC component 1; Belongs to the argonaute family. | 0.985 |
AGO2 | DDX17 | ENSCPOP00000032420 | ENSCPOP00000026093 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | DEAD-box helicase 17; Belongs to the DEAD box helicase family. | 0.424 |
AGO2 | DDX5 | ENSCPOP00000032420 | ENSCPOP00000006432 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | DEAD-box helicase 5; Belongs to the DEAD box helicase family. | 0.607 |
AGO2 | DGCR8 | ENSCPOP00000032420 | ENSCPOP00000028717 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | DGCR8 microprocessor complex subunit. | 0.856 |
AGO2 | DROSHA | ENSCPOP00000032420 | ENSCPOP00000013567 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Drosha ribonuclease III. | 0.972 |
AGO2 | TARBP2 | ENSCPOP00000032420 | ENSCPOP00000030982 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] | 0.984 |
DDX17 | AGO2 | ENSCPOP00000026093 | ENSCPOP00000032420 | DEAD-box helicase 17; Belongs to the DEAD box helicase family. | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | 0.424 |
DDX17 | DDX5 | ENSCPOP00000026093 | ENSCPOP00000006432 | DEAD-box helicase 17; Belongs to the DEAD box helicase family. | DEAD-box helicase 5; Belongs to the DEAD box helicase family. | 0.937 |
DDX17 | DGCR8 | ENSCPOP00000026093 | ENSCPOP00000028717 | DEAD-box helicase 17; Belongs to the DEAD box helicase family. | DGCR8 microprocessor complex subunit. | 0.730 |
DDX17 | DROSHA | ENSCPOP00000026093 | ENSCPOP00000013567 | DEAD-box helicase 17; Belongs to the DEAD box helicase family. | Drosha ribonuclease III. | 0.945 |
DDX5 | AGO2 | ENSCPOP00000006432 | ENSCPOP00000032420 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | 0.607 |
DDX5 | DDX17 | ENSCPOP00000006432 | ENSCPOP00000026093 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. | DEAD-box helicase 17; Belongs to the DEAD box helicase family. | 0.937 |
DDX5 | DGCR8 | ENSCPOP00000006432 | ENSCPOP00000028717 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. | DGCR8 microprocessor complex subunit. | 0.703 |
DDX5 | DROSHA | ENSCPOP00000006432 | ENSCPOP00000013567 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. | Drosha ribonuclease III. | 0.970 |
DGCR8 | AGO1 | ENSCPOP00000028717 | ENSCPOP00000027610 | DGCR8 microprocessor complex subunit. | Argonaute RISC component 1; Belongs to the argonaute family. | 0.624 |
DGCR8 | AGO2 | ENSCPOP00000028717 | ENSCPOP00000032420 | DGCR8 microprocessor complex subunit. | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | 0.856 |