CCBE1 protein (Cavia porcellus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CCBE1

Collagen and calcium binding EGF domains 1. (392 aa)

Predicted Functional Partners:

VEGFC

0.788

ADAMTS3

0.721

TNFRSF13C

0.633

C8B

0.629

ACTG2

0.624

VEGFD

0.617

TNFRSF17

0.606

IL33

0.599

C7

0.598

ADAMTS14

0.588

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTG2	CCBE1	ENSCPOP00000032504	ENSCPOP00000013777	Actin gamma 2, smooth muscle.	Collagen and calcium binding EGF domains 1.	0.624
ADAMTS14	CCBE1	ENSCPOP00000015706	ENSCPOP00000013777	ADAM metallopeptidase with thrombospondin type 1 motif 14.	Collagen and calcium binding EGF domains 1.	0.588
ADAMTS3	CCBE1	ENSCPOP00000019122	ENSCPOP00000013777	Uncharacterized protein.	Collagen and calcium binding EGF domains 1.	0.721
ADAMTS3	VEGFC	ENSCPOP00000019122	ENSCPOP00000031110	Uncharacterized protein.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.459
C7	C8B	ENSCPOP00000014133	ENSCPOP00000022760	Complement C7.	Complement C8 beta chain.	0.988
C7	CCBE1	ENSCPOP00000014133	ENSCPOP00000013777	Complement C7.	Collagen and calcium binding EGF domains 1.	0.598
C8B	C7	ENSCPOP00000022760	ENSCPOP00000014133	Complement C8 beta chain.	Complement C7.	0.988
C8B	CCBE1	ENSCPOP00000022760	ENSCPOP00000013777	Complement C8 beta chain.	Collagen and calcium binding EGF domains 1.	0.629
CCBE1	ACTG2	ENSCPOP00000013777	ENSCPOP00000032504	Collagen and calcium binding EGF domains 1.	Actin gamma 2, smooth muscle.	0.624
CCBE1	ADAMTS14	ENSCPOP00000013777	ENSCPOP00000015706	Collagen and calcium binding EGF domains 1.	ADAM metallopeptidase with thrombospondin type 1 motif 14.	0.588
CCBE1	ADAMTS3	ENSCPOP00000013777	ENSCPOP00000019122	Collagen and calcium binding EGF domains 1.	Uncharacterized protein.	0.721
CCBE1	C7	ENSCPOP00000013777	ENSCPOP00000014133	Collagen and calcium binding EGF domains 1.	Complement C7.	0.598
CCBE1	C8B	ENSCPOP00000013777	ENSCPOP00000022760	Collagen and calcium binding EGF domains 1.	Complement C8 beta chain.	0.629
CCBE1	IL33	ENSCPOP00000013777	ENSCPOP00000033054	Collagen and calcium binding EGF domains 1.	Interleukin 33.	0.599
CCBE1	TNFRSF13C	ENSCPOP00000013777	ENSCPOP00000033078	Collagen and calcium binding EGF domains 1.	TNF receptor superfamily member 13C.	0.633
CCBE1	TNFRSF17	ENSCPOP00000013777	ENSCPOP00000017664	Collagen and calcium binding EGF domains 1.	TNF receptor superfamily member 17.	0.606
CCBE1	VEGFC	ENSCPOP00000013777	ENSCPOP00000031110	Collagen and calcium binding EGF domains 1.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.788
CCBE1	VEGFD	ENSCPOP00000013777	ENSCPOP00000003637	Collagen and calcium binding EGF domains 1.	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	0.617
IL33	CCBE1	ENSCPOP00000033054	ENSCPOP00000013777	Interleukin 33.	Collagen and calcium binding EGF domains 1.	0.599
TNFRSF13C	CCBE1	ENSCPOP00000033078	ENSCPOP00000013777	TNF receptor superfamily member 13C.	Collagen and calcium binding EGF domains 1.	0.633

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.719

expected number of edges:

26

PPI enrichment p-value:

0.521

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140647

P450-containing electron transport chain

2 of 2

3.28

1.33

0.0040

GO:0006091

Generation of precursor metabolites and energy

5 of 283

1.53

1.31

0.00094

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009055

Electron transfer activity

4 of 66

2.06

2.01

9.76e-05

GO:0051536

Iron-sulfur cluster binding

4 of 79

1.99

1.97

9.76e-05

GO:0016651

Oxidoreductase activity, acting on NAD(P)H

3 of 58

1.99

1.38

0.0020

GO:0016491

Oxidoreductase activity

6 of 793

1.16

1.02

0.00078

GO:0004312

Fatty acid synthase activity

2 of 19

2.3

0.92

0.0198

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005739

Mitochondrion

6 of 1409

0.91

0.5

0.0399

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23332

Mixed, incl. Retinol metabolism, and Valine, leucine and isoleucine degradation

4 of 181

1.63

1.01

0.0080

CL:23532

Mixed, incl. Beta-ketoacyl synthase, C-terminal domain, and Acyl transferase domain

2 of 6

2.8

1.01

0.0152

CL:23336

Mixed, incl. Valine, leucine and isoleucine degradation, and Fatty acid biosynthesis

3 of 133

1.63

0.68

0.0460

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

4 of 200

1.58

1.53

0.00026

map00061

Fatty acid biosynthesis

2 of 32

2.08

1.08

0.0090

map00860

Porphyrin and chlorophyll metabolism

2 of 85

1.65

0.69

0.0444

map01212

Fatty acid metabolism

2 of 93

1.61

0.68

0.0444

map01100

Metabolic pathways

9 of 3033

0.75

0.65

0.00022

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2395516

Electron transport from NADPH to Ferredoxin

2 of 4

2.98

1.22

0.0062

MAP-196108

Pregnenolone biosynthesis

2 of 13

2.47

0.91

0.0217

MAP-1362409

Mitochondrial iron-sulfur cluster biogenesis

2 of 16

2.38

0.91

0.0217

MAP-211945

Phase I - Functionalization of compounds

3 of 125

1.66

0.83

0.0217

MAP-211976

Endogenous sterols

2 of 36

2.03

0.73

0.0443

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005739

Mitochondrion

6 of 892

1.11

0.84

0.0035

GOCC:0005747

Mitochondrial respiratory chain complex I

2 of 26

2.17

0.72

0.0475

GOCC:0005737

Cytoplasm

10 of 6155

0.49

0.33

0.0290

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00037

4Fe-4S binding domain

2 of 3

3.1

1.25

0.0057

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR010226

NADH-quinone oxidoreductase, chain I

2 of 2

3.28

1.11

0.0101

IPR001055

Adrenodoxin

2 of 2

3.28

1.11

0.0101

IPR017900

4Fe-4S ferredoxin, iron-sulphur binding, conserved site

2 of 6

2.8

1.0

0.0157

IPR036010

2Fe-2S ferredoxin-like superfamily

2 of 8

2.68

0.95

0.0190

IPR017896

4Fe-4S ferredoxin-type, iron-sulphur binding domain

2 of 10

2.58

0.91

0.0222

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About