STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NR3C1Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] (772 aa)    
Predicted Functional Partners:
NCOA2
Nuclear receptor coactivator.
   
 0.991
PTGES3
Prostaglandin E synthase 3.
   
 0.990
NCOR1
Nuclear receptor corepressor 1.
    
 0.988
NCOA1
Nuclear receptor coactivator.
   
 0.985
STIP1
Stress induced phosphoprotein 1.
    
 0.964
PPARGC1A
PPARG coactivator 1 alpha.
    
 0.955
Hsp90aa1
Heat shock protein 90 alpha family class A member 1.
    
 0.940
HSP90AB1
Heat shock protein 90 alpha family class B member 1.
    
 0.940
LOC100725824
HATPase_c domain-containing protein.
    
 0.940
FKBP5
Peptidylprolyl isomerase.
    
 0.939
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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