NHLH2 protein (Cavia porcellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

NHLH2

Nescient helix-loop-helix 2. (135 aa)

Predicted Functional Partners:

LDB2

0.740

LDB1

0.739

TCF4

0.729

TCF12

0.729

TCF3

0.729

PCSK1

0.594

RUNX3

0.537

GSC

0.529

RUNX1

0.528

OTP

0.521

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GSC	LDB1	ENSCPOP00000018060	ENSCPOP00000009260	Goosecoid homeobox.	LIM domain binding 1.	0.613
GSC	LDB2	ENSCPOP00000018060	ENSCPOP00000022415	Goosecoid homeobox.	LIM domain binding 2.	0.613
GSC	NHLH2	ENSCPOP00000018060	ENSCPOP00000015430	Goosecoid homeobox.	Nescient helix-loop-helix 2.	0.529
GSC	TCF12	ENSCPOP00000018060	ENSCPOP00000008217	Goosecoid homeobox.	Transcription factor 12.	0.495
GSC	TCF3	ENSCPOP00000018060	ENSCPOP00000029307	Goosecoid homeobox.	Transcription factor 3.	0.500
GSC	TCF4	ENSCPOP00000018060	ENSCPOP00000004736	Goosecoid homeobox.	Transcription factor 4.	0.495
LDB1	GSC	ENSCPOP00000009260	ENSCPOP00000018060	LIM domain binding 1.	Goosecoid homeobox.	0.613
LDB1	NHLH2	ENSCPOP00000009260	ENSCPOP00000015430	LIM domain binding 1.	Nescient helix-loop-helix 2.	0.739
LDB1	OTP	ENSCPOP00000009260	ENSCPOP00000008872	LIM domain binding 1.	Orthopedia homeobox.	0.613
LDB1	RUNX1	ENSCPOP00000009260	ENSCPOP00000021315	LIM domain binding 1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.651
LDB1	RUNX3	ENSCPOP00000009260	ENSCPOP00000030407	LIM domain binding 1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.621
LDB1	TCF12	ENSCPOP00000009260	ENSCPOP00000008217	LIM domain binding 1.	Transcription factor 12.	0.816
LDB1	TCF3	ENSCPOP00000009260	ENSCPOP00000029307	LIM domain binding 1.	Transcription factor 3.	0.885
LDB1	TCF4	ENSCPOP00000009260	ENSCPOP00000004736	LIM domain binding 1.	Transcription factor 4.	0.877
LDB2	GSC	ENSCPOP00000022415	ENSCPOP00000018060	LIM domain binding 2.	Goosecoid homeobox.	0.613
LDB2	NHLH2	ENSCPOP00000022415	ENSCPOP00000015430	LIM domain binding 2.	Nescient helix-loop-helix 2.	0.740
LDB2	OTP	ENSCPOP00000022415	ENSCPOP00000008872	LIM domain binding 2.	Orthopedia homeobox.	0.613
LDB2	RUNX1	ENSCPOP00000022415	ENSCPOP00000021315	LIM domain binding 2.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.618
LDB2	RUNX3	ENSCPOP00000022415	ENSCPOP00000030407	LIM domain binding 2.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.618
LDB2	TCF12	ENSCPOP00000022415	ENSCPOP00000008217	LIM domain binding 2.	Transcription factor 12.	0.754