| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CSF3 | GH1 | ENSCPOP00000013637 | ENSCPOP00000030591 | Colony stimulating factor 3. | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. | 0.910 |
| CSF3 | IL2 | ENSCPOP00000013637 | ENSCPOP00000007430 | Colony stimulating factor 3. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | 0.960 |
| CSF3 | Il4 | ENSCPOP00000013637 | ENSCPOP00000031420 | Colony stimulating factor 3. | Interleukin-4. | 0.955 |
| CSF3 | LEP | ENSCPOP00000013637 | ENSCPOP00000029200 | Colony stimulating factor 3. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.923 |
| GH1 | CSF3 | ENSCPOP00000030591 | ENSCPOP00000013637 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. | Colony stimulating factor 3. | 0.910 |
| GH1 | GHR | ENSCPOP00000030591 | ENSCPOP00000026579 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity); Belongs to the type I cytokine receptor family. Type 1 subfamily. | 0.991 |
| GH1 | GHRH | ENSCPOP00000030591 | ENSCPOP00000014639 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. | Growth hormone releasing hormone. | 0.943 |
| GH1 | GHRL | ENSCPOP00000030591 | ENSCPOP00000019867 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. | Ghrelin and obestatin prepropeptide. | 0.935 |
| GH1 | H0WD65_CAVPO | ENSCPOP00000030591 | ENSCPOP00000020937 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. | Uncharacterized protein. | 0.939 |
| GH1 | IL2 | ENSCPOP00000030591 | ENSCPOP00000007430 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | 0.916 |
| GH1 | Il4 | ENSCPOP00000030591 | ENSCPOP00000031420 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. | Interleukin-4. | 0.913 |
| GH1 | LEP | ENSCPOP00000030591 | ENSCPOP00000029200 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.930 |
| GH1 | POMC | ENSCPOP00000030591 | ENSCPOP00000020054 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. | Corticotropin-like intermediary peptide; ACTH stimulates the adrenal glands to release cortisol. Beta-endorphin and Met-enkephalin are endogenous opiates. [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. [Beta-endorphin]: Endogenous orexigenic opiate. | 0.912 |
| GH1 | PRLR | ENSCPOP00000030591 | ENSCPOP00000031707 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. | Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin. | 0.946 |
| GHR | GH1 | ENSCPOP00000026579 | ENSCPOP00000030591 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity); Belongs to the type I cytokine receptor family. Type 1 subfamily. | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. | 0.991 |
| GHR | GHRH | ENSCPOP00000026579 | ENSCPOP00000014639 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity); Belongs to the type I cytokine receptor family. Type 1 subfamily. | Growth hormone releasing hormone. | 0.553 |
| GHR | GHRL | ENSCPOP00000026579 | ENSCPOP00000019867 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity); Belongs to the type I cytokine receptor family. Type 1 subfamily. | Ghrelin and obestatin prepropeptide. | 0.448 |
| GHR | H0WD65_CAVPO | ENSCPOP00000026579 | ENSCPOP00000020937 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity); Belongs to the type I cytokine receptor family. Type 1 subfamily. | Uncharacterized protein. | 0.632 |
| GHR | IL2 | ENSCPOP00000026579 | ENSCPOP00000007430 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity); Belongs to the type I cytokine receptor family. Type 1 subfamily. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | 0.801 |
| GHR | LEP | ENSCPOP00000026579 | ENSCPOP00000029200 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity); Belongs to the type I cytokine receptor family. Type 1 subfamily. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.849 |