node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BDNF | IGF1R | ENSCPOP00000030529 | ENSCPOP00000004859 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Tyrosine-protein kinase receptor. | 0.871 |
BDNF | MET | ENSCPOP00000030529 | ENSCPOP00000012177 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | MET proto-oncogene, receptor tyrosine kinase. | 0.895 |
BDNF | MST1R | ENSCPOP00000030529 | ENSCPOP00000028150 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Macrophage stimulating 1 receptor. | 0.895 |
BDNF | NGF | ENSCPOP00000030529 | ENSCPOP00000020591 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI. | 0.917 |
BDNF | NTF3 | ENSCPOP00000030529 | ENSCPOP00000016314 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. | 0.875 |
BDNF | NTF4 | ENSCPOP00000030529 | ENSCPOP00000015098 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Neurotrophin 4; Belongs to the NGF-beta family. | 0.986 |
BDNF | NTRK1 | ENSCPOP00000030529 | ENSCPOP00000002894 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Tyrosine-protein kinase receptor. | 0.946 |
BDNF | NTRK2 | ENSCPOP00000030529 | ENSCPOP00000021407 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Tyrosine-protein kinase receptor. | 0.980 |
BDNF | NTRK3 | ENSCPOP00000030529 | ENSCPOP00000024385 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Tyrosine-protein kinase receptor. | 0.925 |
BDNF | SORT1 | ENSCPOP00000030529 | ENSCPOP00000002884 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Sortilin. | 0.933 |
IGF1R | BDNF | ENSCPOP00000004859 | ENSCPOP00000030529 | Tyrosine-protein kinase receptor. | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | 0.871 |
IGF1R | MET | ENSCPOP00000004859 | ENSCPOP00000012177 | Tyrosine-protein kinase receptor. | MET proto-oncogene, receptor tyrosine kinase. | 0.779 |
IGF1R | MST1R | ENSCPOP00000004859 | ENSCPOP00000028150 | Tyrosine-protein kinase receptor. | Macrophage stimulating 1 receptor. | 0.612 |
IGF1R | NGF | ENSCPOP00000004859 | ENSCPOP00000020591 | Tyrosine-protein kinase receptor. | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI. | 0.849 |
IGF1R | NTF3 | ENSCPOP00000004859 | ENSCPOP00000016314 | Tyrosine-protein kinase receptor. | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. | 0.828 |
IGF1R | NTF4 | ENSCPOP00000004859 | ENSCPOP00000015098 | Tyrosine-protein kinase receptor. | Neurotrophin 4; Belongs to the NGF-beta family. | 0.824 |
IGF1R | NTRK1 | ENSCPOP00000004859 | ENSCPOP00000002894 | Tyrosine-protein kinase receptor. | Tyrosine-protein kinase receptor. | 0.471 |
IGF1R | NTRK2 | ENSCPOP00000004859 | ENSCPOP00000021407 | Tyrosine-protein kinase receptor. | Tyrosine-protein kinase receptor. | 0.693 |
IGF1R | NTRK3 | ENSCPOP00000004859 | ENSCPOP00000024385 | Tyrosine-protein kinase receptor. | Tyrosine-protein kinase receptor. | 0.409 |
MET | BDNF | ENSCPOP00000012177 | ENSCPOP00000030529 | MET proto-oncogene, receptor tyrosine kinase. | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | 0.895 |