STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
H0W2Y7_CAVPOCalpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (380 aa)    
Predicted Functional Partners:
CAPNS1
Calpain small subunit 1.
 
 
 0.980
H0V7Z8_CAVPO
Uncharacterized protein.
   
 0.941
CAPN1
Calpain 1; Belongs to the peptidase C2 family.
  
0.841
TLN1
Talin 1.
    
 0.729
H0W5F0_CAVPO
BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.
   
  0.728
BAK1
BCL2 antagonist/killer 1.
   
 
 0.669
IL1A
Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).
     
 0.667
ITSN2
Intersectin 2.
     
 0.644
LRGUK
Leucine rich repeats and guanylate kinase domain containing.
    
 
 0.643
TLNRD1
Talin rod domain containing 1.
    
 0.614
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.