CHKA protein (Cavia porcellus) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

CHKA

Choline kinase alpha. (413 aa)

Predicted Functional Partners:

PCYT2

0.919

RPTOR

0.919

PCYT1A

0.842

PCYT1B

0.842

MLST8

0.837

GPCPD1

0.805

PHOSPHO1

0.793

CHKB

0.777

ACHE

0.777

ETNPPL

0.766

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACHE	CHKA	ENSCPOP00000026437	ENSCPOP00000017520	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Choline kinase alpha.	0.777
ACHE	CHKB	ENSCPOP00000026437	ENSCPOP00000006877	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Choline kinase beta.	0.777
ACHE	GPCPD1	ENSCPOP00000026437	ENSCPOP00000028812	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Glycerophosphocholine phosphodiesterase 1.	0.808
CHKA	ACHE	ENSCPOP00000017520	ENSCPOP00000026437	Choline kinase alpha.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.777
CHKA	CHKB	ENSCPOP00000017520	ENSCPOP00000006877	Choline kinase alpha.	Choline kinase beta.	0.777
CHKA	ETNPPL	ENSCPOP00000017520	ENSCPOP00000013854	Choline kinase alpha.	Ethanolamine-phosphate phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.766
CHKA	GPCPD1	ENSCPOP00000017520	ENSCPOP00000028812	Choline kinase alpha.	Glycerophosphocholine phosphodiesterase 1.	0.805
CHKA	MLST8	ENSCPOP00000017520	ENSCPOP00000001866	Choline kinase alpha.	MTOR associated protein, LST8 homolog.	0.837
CHKA	PCYT1A	ENSCPOP00000017520	ENSCPOP00000022767	Choline kinase alpha.	Phosphate cytidylyltransferase 1, choline, alpha.	0.842
CHKA	PCYT1B	ENSCPOP00000017520	ENSCPOP00000031355	Choline kinase alpha.	Phosphate cytidylyltransferase 1, choline, beta.	0.842
CHKA	PCYT2	ENSCPOP00000017520	ENSCPOP00000001653	Choline kinase alpha.	Phosphate cytidylyltransferase 2, ethanolamine.	0.919
CHKA	PHOSPHO1	ENSCPOP00000017520	ENSCPOP00000020703	Choline kinase alpha.	Phosphoethanolamine/phosphocholine phosphatase.	0.793
CHKA	RPTOR	ENSCPOP00000017520	ENSCPOP00000031665	Choline kinase alpha.	Regulatory associated protein of MTOR complex 1.	0.919
CHKB	ACHE	ENSCPOP00000006877	ENSCPOP00000026437	Choline kinase beta.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.777
CHKB	CHKA	ENSCPOP00000006877	ENSCPOP00000017520	Choline kinase beta.	Choline kinase alpha.	0.777
CHKB	ETNPPL	ENSCPOP00000006877	ENSCPOP00000013854	Choline kinase beta.	Ethanolamine-phosphate phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.911
CHKB	GPCPD1	ENSCPOP00000006877	ENSCPOP00000028812	Choline kinase beta.	Glycerophosphocholine phosphodiesterase 1.	0.930
CHKB	MLST8	ENSCPOP00000006877	ENSCPOP00000001866	Choline kinase beta.	MTOR associated protein, LST8 homolog.	0.837
CHKB	PCYT1A	ENSCPOP00000006877	ENSCPOP00000022767	Choline kinase beta.	Phosphate cytidylyltransferase 1, choline, alpha.	0.937
CHKB	PCYT1B	ENSCPOP00000006877	ENSCPOP00000031355	Choline kinase beta.	Phosphate cytidylyltransferase 1, choline, beta.	0.937

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

53

average node degree:

9.64

avg. local clustering coefficient:

0.968

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1905323

Telomerase holoenzyme complex assembly

5 of 7

3.13

5.35

1.50e-10

GO:0007004

Telomere maintenance via telomerase

5 of 20

2.67

4.38

5.01e-09

GO:0045793

Positive regulation of cell size

4 of 18

2.62

3.24

8.12e-07

GO:0051131

Chaperone-mediated protein complex assembly

4 of 21

2.55

3.14

1.17e-06

GO:0009651

Response to salt stress

4 of 29

2.41

2.94

2.26e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0002135

CTP binding

4 of 4

3.27

4.4

1.03e-08

GO:0017098

Sulfonylurea receptor binding

4 of 5

3.18

4.38

1.03e-08

GO:0032564

dATP binding

4 of 6

3.1

4.37

1.03e-08

GO:0002134

UTP binding

4 of 6

3.1

4.37

1.03e-08

GO:0030235

Nitric-oxide synthase regulator activity

4 of 7

3.03

4.35

1.03e-08

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044294

Dendritic growth cone

4 of 13

2.76

3.63

1.78e-07

GO:0097524

Sperm plasma membrane

4 of 23

2.51

3.32

4.72e-07

GO:0044295

Axonal growth cone

4 of 45

2.22

2.73

3.93e-06

GO:0031526

Brush border membrane

4 of 73

2.01

2.28

1.99e-05

GO:0042470

Melanosome

4 of 92

1.91

2.13

3.04e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7000

Hsp90 protein, and Hsp90 protein binding

6 of 23

2.69

5.73

9.33e-12

CL:7001

Mixed, incl. Telomerase holoenzyme complex assembly, and FK506 binding

5 of 14

2.83

5.02

3.93e-10

CL:18608

Sulfur-containing amino acid secondary active transmembrane transporter activity, and inositol-1,4-bisphosphate 1-phosphatase activity

2 of 5

2.87

1.36

0.0035

CL:7017

Mixed, incl. CTP binding, and SGS domain

2 of 6

2.8

1.32

0.0041

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3371511

HSF1 activation

5 of 27

2.54

4.44

2.55e-09

MAP-3371568

Attenuation phase

5 of 29

2.51

4.41

2.55e-09

MAP-3371497

HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

6 of 72

2.19

4.12

1.88e-09

MAP-3371571

HSF1-dependent transactivation

5 of 48

2.29

3.82

1.81e-08

MAP-399954

Sema3A PAK dependent Axon repulsion

4 of 27

2.44

3.29

4.69e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0044294

Dendritic growth cone

3 of 12

2.67

2.17

9.97e-05

GOCC:0030426

Growth cone

4 of 141

1.73

1.54

0.00048

GOCC:0101031

Chaperone complex

2 of 34

2.04

0.72

0.0449

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0346

Stress response

5 of 29

2.51

4.49

1.71e-09

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00183

Hsp90 protein

5 of 6

3.19

5.9

1.57e-11

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00387

Histidine kinase-like ATPases

3 of 15

2.57

2.23

7.18e-05

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