ESR2 protein (Cavia porcellus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ESR2

Estrogen receptor 2. (568 aa)

Predicted Functional Partners:

NCOA1

0.997

ESR1

0.982

NCOA2

0.972

MED1

0.970

NCOA3

0.961

NCOR1

0.957

FOS

0.953

SP1

0.949

MAPK1

0.938

MAPK3

0.938

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ESR1	ESR2	ENSCPOP00000007475	ENSCPOP00000017661	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Estrogen receptor 2.	0.982
ESR1	FOS	ENSCPOP00000007475	ENSCPOP00000021851	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.953
ESR1	MAPK1	ENSCPOP00000007475	ENSCPOP00000011740	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Mitogen-activated protein kinase.	0.833
ESR1	MAPK3	ENSCPOP00000007475	ENSCPOP00000024212	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.849
ESR1	MED1	ENSCPOP00000007475	ENSCPOP00000030135	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.974
ESR1	NCOA1	ENSCPOP00000007475	ENSCPOP00000023829	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.999
ESR1	NCOA2	ENSCPOP00000007475	ENSCPOP00000022093	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.998
ESR1	NCOA3	ENSCPOP00000007475	ENSCPOP00000007263	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.996
ESR1	NCOR1	ENSCPOP00000007475	ENSCPOP00000000762	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor corepressor 1.	0.966
ESR1	SP1	ENSCPOP00000007475	ENSCPOP00000018716	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Sp1 transcription factor.	0.987
ESR2	ESR1	ENSCPOP00000017661	ENSCPOP00000007475	Estrogen receptor 2.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.982
ESR2	FOS	ENSCPOP00000017661	ENSCPOP00000021851	Estrogen receptor 2.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.953
ESR2	MAPK1	ENSCPOP00000017661	ENSCPOP00000011740	Estrogen receptor 2.	Mitogen-activated protein kinase.	0.938
ESR2	MAPK3	ENSCPOP00000017661	ENSCPOP00000024212	Estrogen receptor 2.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.938
ESR2	MED1	ENSCPOP00000017661	ENSCPOP00000030135	Estrogen receptor 2.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.970
ESR2	NCOA1	ENSCPOP00000017661	ENSCPOP00000023829	Estrogen receptor 2.	Nuclear receptor coactivator.	0.997
ESR2	NCOA2	ENSCPOP00000017661	ENSCPOP00000022093	Estrogen receptor 2.	Nuclear receptor coactivator.	0.972
ESR2	NCOA3	ENSCPOP00000017661	ENSCPOP00000007263	Estrogen receptor 2.	Nuclear receptor coactivator.	0.961
ESR2	NCOR1	ENSCPOP00000017661	ENSCPOP00000000762	Estrogen receptor 2.	Nuclear receptor corepressor 1.	0.957
ESR2	SP1	ENSCPOP00000017661	ENSCPOP00000018716	Estrogen receptor 2.	Sp1 transcription factor.	0.949