STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Defb128Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (103 aa)    
Predicted Functional Partners:
DEFB124
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
     
 0.815
DEFB113
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.647
DEFB110
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.645
DEFB123
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
     
 0.635
ENSCPOP00000031589
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
     
 0.618
DEFB127
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
     
 0.516
IL10
Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]
      
 0.459
DEFB136
Defensin beta 136.
     
 0.401
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.