STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
INSRRInsulin receptor-related protein alpha chain; Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB (By similarity). (1300 aa)    
Predicted Functional Partners:
INS
Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    
 0.978
PTPN1
Tyrosine-protein phosphatase non-receptor type.
    
 0.966
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
    
 0.963
GRB2
Growth factor receptor bound protein 2.
   
 0.943
PIK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
    
 0.938
IGF1R
Tyrosine-protein kinase receptor.
  
 
0.927
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
    
 0.926
SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2.
    
 0.924
INSR
Tyrosine-protein kinase receptor.
  
 
 
0.919
H0W027_CAVPO
Uncharacterized protein.
    
 0.913
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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