STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIGMAR1Sigma non-opioid intracellular receptor 1; Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. [...] (223 aa)    
Predicted Functional Partners:
ERG28
Ergosterol biosynthesis 28 homolog.
   
 
 0.994
CYP51A1
Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.
   
 
 0.994
SQLE
Squalene epoxidase.
   
 
 0.994
SC5D
Sterol-C5-desaturase; Belongs to the sterol desaturase family.
   
 0.989
MSMO1
Methylsterol monooxygenase 1; Belongs to the sterol desaturase family.
   
 0.978
CH25H
Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.
   
 0.978
FAXDC2
Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family.
   
 0.978
FBXO43
F-box protein 43.
   
 0.952
RGS22
Regulator of G protein signaling 22.
   
 0.952
Lbr
Tudor domain-containing protein.
   
 
 0.934
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.