STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RNF227Ring finger protein 227. (190 aa)    
Predicted Functional Partners:
GAS7
Growth arrest specific 7.
    
  0.535
H0W3J0_CAVPO
Uncharacterized protein.
    
 0.498
ICOS
Inducible T cell costimulator.
    
  0.490
TONSL
Tonsoku like, DNA repair protein.
    
  0.468
Rps27a
Ubiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...]
    
  0.458
H0WAD6_CAVPO
Ubiquitin-like domain-containing protein.
    
  0.458
ENSCPOP00000031632
Ubiquitin-like domain-containing protein.
    
  0.458
UBE2L6
Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family.
    
  0.451
Ube2l3
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
    
  0.451
KCTD2
Potassium channel tetramerization domain containing 2.
    
  0.424
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.