node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1QA | C3 | ENSCPOP00000031712 | ENSCPOP00000018087 | Complement C1q A chain. | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | 0.844 |
C1QA | C3AR1 | ENSCPOP00000031712 | ENSCPOP00000019559 | Complement C1q A chain. | C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. | 0.723 |
C1QA | C5 | ENSCPOP00000031712 | ENSCPOP00000002041 | Complement C1q A chain. | Complement C5. | 0.480 |
C1QA | H0W7A0_CAVPO | ENSCPOP00000031712 | ENSCPOP00000018854 | Complement C1q A chain. | NTR domain-containing protein. | 0.731 |
C1QA | LOC100728345 | ENSCPOP00000031712 | ENSCPOP00000022343 | Complement C1q A chain. | Anaphylatoxin-like domain-containing protein. | 0.927 |
C3 | C1QA | ENSCPOP00000018087 | ENSCPOP00000031712 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Complement C1q A chain. | 0.844 |
C3 | C3AR1 | ENSCPOP00000018087 | ENSCPOP00000019559 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. | 0.950 |
C3 | C5 | ENSCPOP00000018087 | ENSCPOP00000002041 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Complement C5. | 0.935 |
C3 | C5AR1 | ENSCPOP00000018087 | ENSCPOP00000028128 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.626 |
C3 | C5AR2 | ENSCPOP00000018087 | ENSCPOP00000016217 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Complement component 5a receptor 2. | 0.626 |
C3 | H0W7A0_CAVPO | ENSCPOP00000018087 | ENSCPOP00000018854 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | NTR domain-containing protein. | 0.536 |
C3 | POMC | ENSCPOP00000018087 | ENSCPOP00000020054 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Corticotropin-like intermediary peptide; ACTH stimulates the adrenal glands to release cortisol. Beta-endorphin and Met-enkephalin are endogenous opiates. [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. [Beta-endorphin]: Endogenous orexigenic opiate. | 0.635 |
C3AR1 | C1QA | ENSCPOP00000019559 | ENSCPOP00000031712 | C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. | Complement C1q A chain. | 0.723 |
C3AR1 | C3 | ENSCPOP00000019559 | ENSCPOP00000018087 | C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | 0.950 |
C3AR1 | C5 | ENSCPOP00000019559 | ENSCPOP00000002041 | C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. | Complement C5. | 0.922 |
C3AR1 | C5AR1 | ENSCPOP00000019559 | ENSCPOP00000028128 | C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. | C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.714 |
C3AR1 | C5AR2 | ENSCPOP00000019559 | ENSCPOP00000016217 | C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. | Complement component 5a receptor 2. | 0.726 |
C3AR1 | GAL | ENSCPOP00000019559 | ENSCPOP00000003911 | C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. | Galanin and GMAP prepropeptide. | 0.672 |
C3AR1 | H0W7A0_CAVPO | ENSCPOP00000019559 | ENSCPOP00000018854 | C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. | NTR domain-containing protein. | 0.742 |
C3AR1 | LOC100728345 | ENSCPOP00000019559 | ENSCPOP00000022343 | C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. | Anaphylatoxin-like domain-containing protein. | 0.763 |