node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COMT | CYP19A1 | ENSCPOP00000004011 | ENSCPOP00000012443 | Catechol-O-methyltransferase. | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.531 |
COMT | CYP1A1 | ENSCPOP00000004011 | ENSCPOP00000014064 | Catechol-O-methyltransferase. | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | 0.953 |
COMT | CYP1A2 | ENSCPOP00000004011 | ENSCPOP00000017610 | Catechol-O-methyltransferase. | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | 0.797 |
COMT | CYP1B1 | ENSCPOP00000004011 | ENSCPOP00000028327 | Catechol-O-methyltransferase. | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.881 |
COMT | CYP26A1 | ENSCPOP00000004011 | ENSCPOP00000014544 | Catechol-O-methyltransferase. | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.587 |
COMT | CYP26B1 | ENSCPOP00000004011 | ENSCPOP00000005814 | Catechol-O-methyltransferase. | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.494 |
COMT | CYP2E1 | ENSCPOP00000004011 | ENSCPOP00000024284 | Catechol-O-methyltransferase. | Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. | 0.484 |
COMT | ENSCPOP00000027396 | ENSCPOP00000004011 | ENSCPOP00000027396 | Catechol-O-methyltransferase. | Uncharacterized protein. | 0.914 |
COMT | UGT2A3 | ENSCPOP00000004011 | ENSCPOP00000019647 | Catechol-O-methyltransferase. | UDP-glucuronosyltransferase 2A3; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). | 0.695 |
CYP19A1 | COMT | ENSCPOP00000012443 | ENSCPOP00000004011 | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | Catechol-O-methyltransferase. | 0.531 |
CYP19A1 | CYP1A1 | ENSCPOP00000012443 | ENSCPOP00000014064 | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | 0.847 |
CYP19A1 | CYP1A2 | ENSCPOP00000012443 | ENSCPOP00000017610 | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | 0.790 |
CYP19A1 | CYP1B1 | ENSCPOP00000012443 | ENSCPOP00000028327 | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.829 |
CYP19A1 | CYP2E1 | ENSCPOP00000012443 | ENSCPOP00000024284 | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. | 0.569 |
CYP19A1 | HSD11B1 | ENSCPOP00000012443 | ENSCPOP00000005042 | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta- hydroxycholesterol (By similarity). | 0.491 |
CYP19A1 | UGT2A3 | ENSCPOP00000012443 | ENSCPOP00000019647 | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | UDP-glucuronosyltransferase 2A3; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). | 0.668 |
CYP1A1 | COMT | ENSCPOP00000014064 | ENSCPOP00000004011 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Catechol-O-methyltransferase. | 0.953 |
CYP1A1 | CYP19A1 | ENSCPOP00000014064 | ENSCPOP00000012443 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.847 |
CYP1A1 | CYP1A2 | ENSCPOP00000014064 | ENSCPOP00000017610 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | 0.806 |
CYP1A1 | CYP1B1 | ENSCPOP00000014064 | ENSCPOP00000028327 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.832 |