STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DOCK6Dedicator of cytokinesis 6; Belongs to the DOCK family. (2063 aa)    
Predicted Functional Partners:
CDC42
Cell division cycle 42.
   
 0.887
DOCK8
Dedicator of cytokinesis 8; Belongs to the DOCK family.
  
 
 
0.766
RAC3
Rac family small GTPase 3.
   
 0.746
RAC2
Ras-related C3 botulinum toxin substrate 2; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase (By similarity).
   
 0.746
RAC1
Ras-related C3 botulinum toxin substrate 1.
   
 0.746
RHOG
Ras homolog family member G.
   
 0.705
RHOU
Ras homolog family member U.
   
 0.679
RHOV
Ras homolog family member V.
   
 0.679
LRCH3
Leucine rich repeats and calponin homology domain containing 3.
   
 
 0.656
CRK
CRK proto-oncogene, adaptor protein.
     
 0.628
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.