ASB15 protein (Cavia porcellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ASB15

Ankyrin repeat and SOCS box containing 15. (552 aa)

Predicted Functional Partners:

LOC100721103

0.727

IFT81

0.668

IKBKB

0.651

CUL5

0.641

CHUK

0.636

ASB4

0.635

COMMD1

0.631

COMMD8

0.621

NEDD8

0.619

REL

0.614

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASB15	ASB4	ENSCPOP00000020288	ENSCPOP00000012834	Ankyrin repeat and SOCS box containing 15.	Ankyrin repeat and SOCS box containing 4.	0.635
ASB15	CHUK	ENSCPOP00000020288	ENSCPOP00000032009	Ankyrin repeat and SOCS box containing 15.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.636
ASB15	COMMD1	ENSCPOP00000020288	ENSCPOP00000001891	Ankyrin repeat and SOCS box containing 15.	Copper metabolism domain containing 1.	0.631
ASB15	COMMD8	ENSCPOP00000020288	ENSCPOP00000013622	Ankyrin repeat and SOCS box containing 15.	COMM domain containing 8.	0.621
ASB15	CUL5	ENSCPOP00000020288	ENSCPOP00000027039	Ankyrin repeat and SOCS box containing 15.	Cullin 5; Belongs to the cullin family.	0.641
ASB15	IFT81	ENSCPOP00000020288	ENSCPOP00000013342	Ankyrin repeat and SOCS box containing 15.	Intraflagellar transport 81.	0.668
ASB15	IKBKB	ENSCPOP00000020288	ENSCPOP00000009478	Ankyrin repeat and SOCS box containing 15.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.651
ASB15	LOC100721103	ENSCPOP00000020288	ENSCPOP00000000603	Ankyrin repeat and SOCS box containing 15.	TPR_REGION domain-containing protein.	0.727
ASB15	NEDD8	ENSCPOP00000020288	ENSCPOP00000009821	Ankyrin repeat and SOCS box containing 15.	NEDD8 ubiquitin like modifier.	0.619
ASB15	REL	ENSCPOP00000020288	ENSCPOP00000010485	Ankyrin repeat and SOCS box containing 15.	REL proto-oncogene, NF-kB subunit.	0.614
ASB4	ASB15	ENSCPOP00000012834	ENSCPOP00000020288	Ankyrin repeat and SOCS box containing 4.	Ankyrin repeat and SOCS box containing 15.	0.635
ASB4	COMMD1	ENSCPOP00000012834	ENSCPOP00000001891	Ankyrin repeat and SOCS box containing 4.	Copper metabolism domain containing 1.	0.745
ASB4	COMMD8	ENSCPOP00000012834	ENSCPOP00000013622	Ankyrin repeat and SOCS box containing 4.	COMM domain containing 8.	0.612
ASB4	CUL5	ENSCPOP00000012834	ENSCPOP00000027039	Ankyrin repeat and SOCS box containing 4.	Cullin 5; Belongs to the cullin family.	0.746
ASB4	IFT81	ENSCPOP00000012834	ENSCPOP00000013342	Ankyrin repeat and SOCS box containing 4.	Intraflagellar transport 81.	0.668
ASB4	LOC100721103	ENSCPOP00000012834	ENSCPOP00000000603	Ankyrin repeat and SOCS box containing 4.	TPR_REGION domain-containing protein.	0.630
ASB4	NEDD8	ENSCPOP00000012834	ENSCPOP00000009821	Ankyrin repeat and SOCS box containing 4.	NEDD8 ubiquitin like modifier.	0.609
CHUK	ASB15	ENSCPOP00000032009	ENSCPOP00000020288	Component of inhibitor of nuclear factor kappa B kinase complex.	Ankyrin repeat and SOCS box containing 15.	0.636
CHUK	IKBKB	ENSCPOP00000032009	ENSCPOP00000009478	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.999
CHUK	REL	ENSCPOP00000032009	ENSCPOP00000010485	Component of inhibitor of nuclear factor kappa B kinase complex.	REL proto-oncogene, NF-kB subunit.	0.925

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

22

PPI enrichment p-value:

2.18e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 487

1.63

3.71

1.87e-14

GO:0000027

Ribosomal large subunit assembly

3 of 26

2.33

1.87

0.00029

GO:2000435

Negative regulation of protein neddylation

2 of 5

2.87

1.37

0.0033

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

11 of 295

1.84

5.22

2.17e-17

GO:1990948

Ubiquitin ligase inhibitor activity

2 of 8

2.67

1.04

0.0130

GO:0019843

rRNA binding

3 of 85

1.82

0.96

0.0130

GO:0008097

5S rRNA binding

2 of 16

2.37

0.9

0.0221

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005761

Mitochondrial ribosome

8 of 90

2.22

6.08

1.36e-14

GO:0005762

Mitochondrial large ribosomal subunit

7 of 62

2.33

5.87

2.75e-13

GO:0044391

Ribosomal subunit

11 of 286

1.86

5.37

7.90e-18

GO:0015934

Large ribosomal subunit

9 of 181

1.97

5.21

1.23e-14

GO:0098798

Mitochondrial protein-containing complex

8 of 335

1.65

3.18

1.63e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5581

Organellar large ribosomal subunit, and Mitochondrial translational elongation

8 of 11

3.13

10.22

7.02e-20

CL:5583

Mixed, incl. Mitochondrial translational elongation, and Small ribosomal subunit rRNA binding

3 of 5

3.05

3.02

3.19e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ccan03010

Ribosome

11 of 137

2.18

8.1

5.95e-22

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5419276

Mitochondrial translation termination

8 of 99

2.18

5.75

5.63e-14

MAP-5389840

Mitochondrial translation elongation

8 of 100

2.18

5.73

5.63e-14

MAP-5368287

Mitochondrial translation

8 of 106

2.15

5.66

5.63e-14

MAP-72766

Translation

11 of 463

1.65

3.96

1.45e-15

MAP-392499

Metabolism of proteins

11 of 2639

0.89

1.0

5.33e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005761

Mitochondrial ribosome

8 of 93

2.21

5.94

2.65e-14

GOCC:0005762

Mitochondrial large ribosomal subunit

7 of 59

2.35

5.92

2.63e-13

GOCC:0005840

Ribosome

11 of 277

1.87

5.46

6.37e-18

GOCC:0044391

Ribosomal subunit

10 of 219

1.93

5.45

2.49e-16

GOCC:0015934

Large ribosomal subunit

8 of 124

2.08

5.32

1.44e-13

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

11 of 285

1.86

5.49

1.85e-18

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