ADRA1B protein (Cavia porcellus) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

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[Homology]

Score

ADRA1B

Adrenoceptor alpha 1B. (520 aa)

Predicted Functional Partners:

GNA12

0.940

ADRA1A

0.940

GNA11

0.937

GNAQ

0.937

GNA13

0.857

Gna15

0.833

ADRA1D

0.825

GNB5

0.801

EDN1

0.793

EDN3

0.790

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRA1A	ADRA1B	ENSCPOP00000031190	ENSCPOP00000020425	Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).	Adrenoceptor alpha 1B.	0.940
ADRA1A	ADRA1D	ENSCPOP00000031190	ENSCPOP00000022910	Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).	Adrenoceptor alpha 1D.	0.841
ADRA1A	EDN1	ENSCPOP00000031190	ENSCPOP00000028977	Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.782
ADRA1A	EDN3	ENSCPOP00000031190	ENSCPOP00000028662	Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).	Endothelin 3.	0.790
ADRA1A	GNA11	ENSCPOP00000031190	ENSCPOP00000021515	Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).	G protein subunit alpha 11.	0.940
ADRA1A	GNA12	ENSCPOP00000031190	ENSCPOP00000001605	Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).	G protein subunit alpha 12.	0.951
ADRA1A	GNA13	ENSCPOP00000031190	ENSCPOP00000011766	Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).	G protein subunit alpha 13.	0.882
ADRA1A	GNAQ	ENSCPOP00000031190	ENSCPOP00000026700	Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).	G protein subunit alpha q.	0.940
ADRA1A	GNB5	ENSCPOP00000031190	ENSCPOP00000012180	Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).	G protein subunit beta 5.	0.819
ADRA1A	Gna15	ENSCPOP00000031190	ENSCPOP00000004478	Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).	Uncharacterized protein.	0.833
ADRA1B	ADRA1A	ENSCPOP00000020425	ENSCPOP00000031190	Adrenoceptor alpha 1B.	Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).	0.940
ADRA1B	ADRA1D	ENSCPOP00000020425	ENSCPOP00000022910	Adrenoceptor alpha 1B.	Adrenoceptor alpha 1D.	0.825
ADRA1B	EDN1	ENSCPOP00000020425	ENSCPOP00000028977	Adrenoceptor alpha 1B.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.793
ADRA1B	EDN3	ENSCPOP00000020425	ENSCPOP00000028662	Adrenoceptor alpha 1B.	Endothelin 3.	0.790
ADRA1B	GNA11	ENSCPOP00000020425	ENSCPOP00000021515	Adrenoceptor alpha 1B.	G protein subunit alpha 11.	0.937
ADRA1B	GNA12	ENSCPOP00000020425	ENSCPOP00000001605	Adrenoceptor alpha 1B.	G protein subunit alpha 12.	0.940
ADRA1B	GNA13	ENSCPOP00000020425	ENSCPOP00000011766	Adrenoceptor alpha 1B.	G protein subunit alpha 13.	0.857
ADRA1B	GNAQ	ENSCPOP00000020425	ENSCPOP00000026700	Adrenoceptor alpha 1B.	G protein subunit alpha q.	0.937
ADRA1B	GNB5	ENSCPOP00000020425	ENSCPOP00000012180	Adrenoceptor alpha 1B.	G protein subunit beta 5.	0.801
ADRA1B	Gna15	ENSCPOP00000020425	ENSCPOP00000004478	Adrenoceptor alpha 1B.	Uncharacterized protein.	0.833

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.687

expected number of edges:

18

PPI enrichment p-value:

0.0101

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006865

Amino acid transport

5 of 49

1.86

2.28

9.20e-06

GO:0015803

Branched-chain amino acid transport

2 of 2

2.85

1.37

0.0033

GO:0003333

Amino acid transmembrane transport

2 of 8

2.24

0.91

0.0206

GO:0000160

Phosphorelay signal transduction system

4 of 219

1.11

0.61

0.0315

GO:0006810

Transport

6 of 718

0.77

0.46

0.0315

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

4 of 116

1.38

0.82

0.0148

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009274

Peptidoglycan-based cell wall

4 of 302

0.97

0.55

0.0314

GO:0005886

Plasma membrane

9 of 1854

0.53

0.37

0.0134

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9153

Mixed, incl. Leucine-binding protein domain, and ANTAR domain

10 of 13

2.73

10.83

1.00e-22

CL:9168

Branched-chain amino acid transport, and Leucine-binding protein domain

5 of 5

2.85

5.17

2.13e-10

CL:9155

ANTAR domain, and Leucine-binding protein domain

3 of 5

2.63

2.37

4.04e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

6 of 380

1.05

0.9

0.00080

map02024

Quorum sensing

5 of 302

1.07

0.83

0.0026

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005561

ANTAR domain

3 of 5

2.63

1.95

0.00026

IPR029016

GAF-like domain superfamily

4 of 34

1.92

1.75

0.00026

IPR003018

GAF domain

3 of 16

2.12

1.47

0.0015

IPR028081

Leucine-binding protein domain

2 of 3

2.67

1.1

0.0101

IPR012074

GAF-ANTAR transcription anti-termination regulator, putative

2 of 3

2.67

1.1

0.0101

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01012

ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.

3 of 5

2.63

2.68

1.02e-05

SM00065

Domain present in phytochromes and cGMP-specific phosphodiesterases.

4 of 22

2.11

2.58

5.57e-06

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