STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (231 aa)    
Predicted Functional Partners:
TNFSF13
TNF superfamily member 13; Belongs to the tumor necrosis factor family.
 
 
 0.944
TNFRSF12A
TNF receptor superfamily member 12A.
    
 0.928
TNFSF13B
TNF superfamily member 13b; Belongs to the tumor necrosis factor family.
   
 0.839
TNF
Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]
   
 
 0.806
TNFSF11
Tumor necrosis factor ligand superfamily member.
     
 0.747
TRAF3
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.707
TRAF5
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.694
BIRC3
Baculoviral IAP repeat containing 3.
    
 0.694
LTBR
Lymphotoxin beta receptor.
   
 
 0.690
TNFRSF13C
TNF receptor superfamily member 13C.
     
 0.684
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.