STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SFTPCSurfactant protein C. (192 aa)    
Predicted Functional Partners:
SFTPB
Uncharacterized protein.
   
 
 0.988
SFTPA1
Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages; Belongs to the SFTPA family.
   
 
 0.968
SFTPD
Surfactant protein D.
   
 
 0.956
AGER
Advanced glycosylation end-product specific receptor.
   
  
 0.861
AQP5
Aquaporin 5; Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
  
 0.796
LOC100727376
C-type lectin domain-containing protein.
   
 
 0.785
PSAP
Saposin-C; Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin- C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.
   
 
 0.766
NAPSA
Napsin A aspartic peptidase; Belongs to the peptidase A1 family.
   
 
 0.766
H0WC94_CAVPO
Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.
   
 
 0.734
CTSH
Cathepsin H; Belongs to the peptidase C1 family.
     
 0.730
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.