HRH3 protein (Cavia porcellus) - STRING interaction network

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HRH3

Histamine H3 receptor; The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist); Belongs to the G-protein coupled receptor 1 family. (369 aa)

Predicted Functional Partners:

HRH2

0.862

HRH1

0.761

HRH4

0.740

CHRM4

0.702

HDC

0.618

DRD2

0.579

HNMT

0.552

CHRM2

0.551

DRD1

0.503

DRD3

0.478

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHRM2	CHRM4	ENSCPOP00000013257	ENSCPOP00000019231	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.702
CHRM2	HRH1	ENSCPOP00000013257	ENSCPOP00000017245	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Histamine H1 receptor; In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.	0.784
CHRM2	HRH2	ENSCPOP00000013257	ENSCPOP00000032709	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family.	0.672
CHRM2	HRH3	ENSCPOP00000013257	ENSCPOP00000020710	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Histamine H3 receptor; The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist); Belongs to the G-protein coupled receptor 1 family.	0.551
CHRM4	CHRM2	ENSCPOP00000019231	ENSCPOP00000013257	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.702
CHRM4	HRH2	ENSCPOP00000019231	ENSCPOP00000032709	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family.	0.712
CHRM4	HRH3	ENSCPOP00000019231	ENSCPOP00000020710	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Histamine H3 receptor; The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist); Belongs to the G-protein coupled receptor 1 family.	0.702
CHRM4	HRH4	ENSCPOP00000019231	ENSCPOP00000001751	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Histamine H4 receptor; Belongs to the G-protein coupled receptor 1 family.	0.721
DRD1	DRD2	ENSCPOP00000025180	ENSCPOP00000008318	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.832
DRD1	DRD3	ENSCPOP00000025180	ENSCPOP00000002322	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.798
DRD1	HRH2	ENSCPOP00000025180	ENSCPOP00000032709	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family.	0.437
DRD1	HRH3	ENSCPOP00000025180	ENSCPOP00000020710	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	Histamine H3 receptor; The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist); Belongs to the G-protein coupled receptor 1 family.	0.503
DRD2	DRD1	ENSCPOP00000008318	ENSCPOP00000025180	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	0.832
DRD2	DRD3	ENSCPOP00000008318	ENSCPOP00000002322	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.829
DRD2	HRH3	ENSCPOP00000008318	ENSCPOP00000020710	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Histamine H3 receptor; The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist); Belongs to the G-protein coupled receptor 1 family.	0.579
DRD2	HRH4	ENSCPOP00000008318	ENSCPOP00000001751	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Histamine H4 receptor; Belongs to the G-protein coupled receptor 1 family.	0.518
DRD3	DRD1	ENSCPOP00000002322	ENSCPOP00000025180	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	0.798
DRD3	DRD2	ENSCPOP00000002322	ENSCPOP00000008318	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.829
DRD3	HRH3	ENSCPOP00000002322	ENSCPOP00000020710	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	Histamine H3 receptor; The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist); Belongs to the G-protein coupled receptor 1 family.	0.478
DRD3	HRH4	ENSCPOP00000002322	ENSCPOP00000001751	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	Histamine H4 receptor; Belongs to the G-protein coupled receptor 1 family.	0.478

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