STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLEKHA5Pleckstrin homology domain containing A5. (1260 aa)    
Predicted Functional Partners:
LATS1
Large tumor suppressor kinase 1.
    
 0.748
LATS2
Non-specific serine/threonine protein kinase.
    
 0.748
PSMD4
Proteasome 26S subunit, non-ATPase 4.
    
 0.734
ADGRA1
Adhesion G protein-coupled receptor A1; Belongs to the G-protein coupled receptor 2 family.
    
 
 0.727
ITSN2
Intersectin 2.
    
  0.706
TEAD3
Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
    
 0.704
TEAD4
Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
    
 0.704
TEAD1
TEA domain transcription factor 1.
    
 0.704
TEAD2
TEA domain transcription factor 2.
    
 0.704
BIRC6
Baculoviral IAP repeat containing 6.
    
 0.700
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.