TMUB1 protein (Cavia porcellus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TMUB1

Transmembrane and ubiquitin like domain containing 1. (247 aa)

Predicted Functional Partners:

ERLIN2

0.797

RNF170

0.687

ERLIN1

0.641

TMUB2

0.612

STK3

0.566

STK4

0.566

C6orf120

0.556

FAM8A1

0.553

TMEM259

0.549

RNF5

0.537

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C6orf120	ERLIN1	ENSCPOP00000017085	ENSCPOP00000015663	Chromosome 6 open reading frame 120.	ER lipid raft associated 1.	0.640
C6orf120	ERLIN2	ENSCPOP00000017085	ENSCPOP00000024345	Chromosome 6 open reading frame 120.	ER lipid raft associated 2.	0.598
C6orf120	RNF170	ENSCPOP00000017085	ENSCPOP00000001718	Chromosome 6 open reading frame 120.	Ring finger protein 170.	0.553
C6orf120	TMEM259	ENSCPOP00000017085	ENSCPOP00000010653	Chromosome 6 open reading frame 120.	Transmembrane protein 259.	0.554
C6orf120	TMUB1	ENSCPOP00000017085	ENSCPOP00000025956	Chromosome 6 open reading frame 120.	Transmembrane and ubiquitin like domain containing 1.	0.556
C6orf120	TMUB2	ENSCPOP00000017085	ENSCPOP00000007009	Chromosome 6 open reading frame 120.	Transmembrane and ubiquitin like domain containing 2.	0.509
ERLIN1	C6orf120	ENSCPOP00000015663	ENSCPOP00000017085	ER lipid raft associated 1.	Chromosome 6 open reading frame 120.	0.640
ERLIN1	ERLIN2	ENSCPOP00000015663	ENSCPOP00000024345	ER lipid raft associated 1.	ER lipid raft associated 2.	0.982
ERLIN1	RNF170	ENSCPOP00000015663	ENSCPOP00000001718	ER lipid raft associated 1.	Ring finger protein 170.	0.727
ERLIN1	RNF5	ENSCPOP00000015663	ENSCPOP00000022511	ER lipid raft associated 1.	Ring finger protein 5.	0.774
ERLIN1	TMEM259	ENSCPOP00000015663	ENSCPOP00000010653	ER lipid raft associated 1.	Transmembrane protein 259.	0.453
ERLIN1	TMUB1	ENSCPOP00000015663	ENSCPOP00000025956	ER lipid raft associated 1.	Transmembrane and ubiquitin like domain containing 1.	0.641
ERLIN1	TMUB2	ENSCPOP00000015663	ENSCPOP00000007009	ER lipid raft associated 1.	Transmembrane and ubiquitin like domain containing 2.	0.663
ERLIN2	C6orf120	ENSCPOP00000024345	ENSCPOP00000017085	ER lipid raft associated 2.	Chromosome 6 open reading frame 120.	0.598
ERLIN2	ERLIN1	ENSCPOP00000024345	ENSCPOP00000015663	ER lipid raft associated 2.	ER lipid raft associated 1.	0.982
ERLIN2	RNF170	ENSCPOP00000024345	ENSCPOP00000001718	ER lipid raft associated 2.	Ring finger protein 170.	0.783
ERLIN2	RNF5	ENSCPOP00000024345	ENSCPOP00000022511	ER lipid raft associated 2.	Ring finger protein 5.	0.790
ERLIN2	TMUB1	ENSCPOP00000024345	ENSCPOP00000025956	ER lipid raft associated 2.	Transmembrane and ubiquitin like domain containing 1.	0.797
ERLIN2	TMUB2	ENSCPOP00000024345	ENSCPOP00000007009	ER lipid raft associated 2.	Transmembrane and ubiquitin like domain containing 2.	0.647
FAM8A1	TMUB1	ENSCPOP00000010692	ENSCPOP00000025956	Family with sequence similarity 8 member A1.	Transmembrane and ubiquitin like domain containing 1.	0.553

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

36

average node degree:

6.55

avg. local clustering coefficient:

0.798

expected number of edges:

19

PPI enrichment p-value:

0.000368

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098657

Import into cell

8 of 146

2.02

4.77

1.94e-12

GO:0140009

L-aspartate import across plasma membrane

4 of 9

2.92

4.21

1.72e-08

GO:0098712

L-glutamate import across plasma membrane

4 of 13

2.76

3.91

5.00e-08

GO:0098810

Neurotransmitter reuptake

4 of 16

2.67

3.76

8.56e-08

GO:0098661

Inorganic anion transmembrane transport

6 of 141

1.91

3.23

2.68e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015370

Solute:sodium symporter activity

10 of 91

2.32

8.12

1.33e-19

GO:0015373

Anion:sodium symporter activity

5 of 12

2.9

5.72

1.93e-11

GO:0005283

Amino acid:sodium symporter activity

5 of 28

2.53

4.74

5.52e-10

GO:0008504

Monoamine transmembrane transporter activity

4 of 8

2.98

4.64

2.75e-09

GO:0015378

Sodium:chloride symporter activity

4 of 11

2.84

4.38

6.88e-09

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045121

Membrane raft

4 of 127

1.77

1.8

0.00012

GO:0005887

Integral component of plasma membrane

9 of 1219

1.14

1.42

5.22e-07

GO:0045202

Synapse

8 of 1045

1.16

1.38

2.52e-06

GO:0032809

Neuronal cell body membrane

2 of 17

2.35

1.22

0.0054

GO:0098793

Presynapse

4 of 370

1.31

0.96

0.0043

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33620468

(2021) Parallel Genomic Changes Drive Repeated Evolution of Placentas in Live-Bearing Fish.

4 of 17

2.65

3.42

3.79e-07

PMID:27272503

(2016) The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis.

4 of 26

2.46

3.17

8.65e-07

PMID:34534441

(2021) Modulation of bioelectric cues in the evolution of flying fishes.

4 of 30

2.4

3.11

9.75e-07

PMID:32275662

(2020) Paternal exposure to a common herbicide alters the behavior and serotonergic system of zebrafish offspring.

2 of 4

2.98

1.58

0.0014

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:36312

Amino acid:sodium symporter activity

10 of 31

2.79

11.38

1.29e-23

CL:36317

Amino acid:sodium symporter activity

9 of 21

2.91

11.01

3.68e-22

CL:36318

Amino acid:sodium symporter activity

6 of 13

2.94

7.12

4.06e-14

CL:36320

Glutamate:sodium symporter activity, and Dopamine:sodium symporter activity

4 of 6

3.1

4.65

2.99e-09

CL:36345

Glutamate:sodium symporter activity, and Dopamine:sodium symporter activity

3 of 6

2.98

3.03

2.88e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

5 of 45

2.32

4.07

5.80e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-425407

SLC-mediated transmembrane transport

8 of 405

1.57

2.67

5.87e-09

MAP-210500

Glutamate Neurotransmitter Release Cycle

4 of 44

2.23

2.66

5.66e-06

MAP-425393

Transport of inorganic cations/anions and amino acids/oligopeptides

5 of 186

1.71

2.09

1.14e-05

MAP-112310

Neurotransmitter release cycle

4 of 98

1.89

2.04

4.84e-05

MAP-442660

Na+/Cl- dependent neurotransmitter transporters

3 of 36

2.2

1.94

0.00018

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 12101

0.23

0.22

0.0235

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032809

Neuronal cell body membrane

2 of 14

2.43

0.74

0.0454

GOCC:0005887

Integral component of plasma membrane

4 of 396

1.28

0.61

0.0454

GOCC:0005886

Plasma membrane

7 of 2381

0.74

0.42

0.0454

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0769

Symport

9 of 54

2.5

8.73

2.12e-19

KW-1133

Transmembrane helix

10 of 4794

0.6

0.5

0.00041

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00209

Sodium:neurotransmitter symporter family

5 of 38

2.4

3.82

2.93e-08

PF00375

Sodium:dicarboxylate symporter family

4 of 16

2.67

3.55

2.20e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR037272

Sodium:neurotransmitter symporter superfamily

5 of 38

2.4

3.59

9.43e-08

IPR000175

Sodium:neurotransmitter symporter

5 of 38

2.4

3.59

9.43e-08

IPR036458

Sodium:dicarboxylate symporter superfamily

4 of 16

2.67

3.38

4.72e-07

IPR001991

Sodium:dicarboxylate symporter

4 of 16

2.67

3.38

4.72e-07

IPR018107

Sodium:dicarboxylate symporter, conserved site

3 of 13

2.64

2.2

8.52e-05

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (20%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About