node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C3 | ITGAL | ENSCPOP00000018087 | ENSCPOP00000006456 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Integrin subunit alpha L; Belongs to the integrin alpha chain family. | 0.623 |
C3 | ITGAM | ENSCPOP00000018087 | ENSCPOP00000026019 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Integrin alpha-M; Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated act [...] | 0.958 |
C3 | ITGB1 | ENSCPOP00000018087 | ENSCPOP00000031829 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Integrin beta; Belongs to the integrin beta chain family. | 0.549 |
C3 | ITGB2 | ENSCPOP00000018087 | ENSCPOP00000014847 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Integrin beta. | 0.775 |
ICAM2 | ITGAL | ENSCPOP00000023966 | ENSCPOP00000006456 | Intercellular adhesion molecule 2. | Integrin subunit alpha L; Belongs to the integrin alpha chain family. | 0.907 |
ICAM2 | ITGAM | ENSCPOP00000023966 | ENSCPOP00000026019 | Intercellular adhesion molecule 2. | Integrin alpha-M; Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated act [...] | 0.893 |
ICAM2 | ITGB1 | ENSCPOP00000023966 | ENSCPOP00000031829 | Intercellular adhesion molecule 2. | Integrin beta; Belongs to the integrin beta chain family. | 0.730 |
ICAM2 | ITGB2 | ENSCPOP00000023966 | ENSCPOP00000014847 | Intercellular adhesion molecule 2. | Integrin beta. | 0.910 |
ITGAL | C3 | ENSCPOP00000006456 | ENSCPOP00000018087 | Integrin subunit alpha L; Belongs to the integrin alpha chain family. | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | 0.623 |
ITGAL | ICAM2 | ENSCPOP00000006456 | ENSCPOP00000023966 | Integrin subunit alpha L; Belongs to the integrin alpha chain family. | Intercellular adhesion molecule 2. | 0.907 |
ITGAL | ITGAM | ENSCPOP00000006456 | ENSCPOP00000026019 | Integrin subunit alpha L; Belongs to the integrin alpha chain family. | Integrin alpha-M; Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated act [...] | 0.974 |
ITGAL | ITGB1 | ENSCPOP00000006456 | ENSCPOP00000031829 | Integrin subunit alpha L; Belongs to the integrin alpha chain family. | Integrin beta; Belongs to the integrin beta chain family. | 0.978 |
ITGAL | ITGB2 | ENSCPOP00000006456 | ENSCPOP00000014847 | Integrin subunit alpha L; Belongs to the integrin alpha chain family. | Integrin beta. | 0.998 |
ITGAL | JAM3 | ENSCPOP00000006456 | ENSCPOP00000005883 | Integrin subunit alpha L; Belongs to the integrin alpha chain family. | Junctional adhesion molecule 3. | 0.663 |
ITGAL | PIK3CB | ENSCPOP00000006456 | ENSCPOP00000000795 | Integrin subunit alpha L; Belongs to the integrin alpha chain family. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.563 |
ITGAL | RAP1A | ENSCPOP00000006456 | ENSCPOP00000033038 | Integrin subunit alpha L; Belongs to the integrin alpha chain family. | RAP1A, member of RAS oncogene family. | 0.911 |
ITGAL | THY1 | ENSCPOP00000006456 | ENSCPOP00000011039 | Integrin subunit alpha L; Belongs to the integrin alpha chain family. | Thy-1 protein. | 0.614 |
ITGAM | C3 | ENSCPOP00000026019 | ENSCPOP00000018087 | Integrin alpha-M; Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated act [...] | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | 0.958 |
ITGAM | ICAM2 | ENSCPOP00000026019 | ENSCPOP00000023966 | Integrin alpha-M; Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated act [...] | Intercellular adhesion molecule 2. | 0.893 |
ITGAM | ITGAL | ENSCPOP00000026019 | ENSCPOP00000006456 | Integrin alpha-M; Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated act [...] | Integrin subunit alpha L; Belongs to the integrin alpha chain family. | 0.974 |