STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FGFR3Fibroblast growth factor receptor. (801 aa)    
Predicted Functional Partners:
FGF1
Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]
    
 0.993
FGF2
Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family.
   
 0.983
FGF8
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.979
FGF18
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.972
FGF23
Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.
    
 0.968
FGF20
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.967
FGF7
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.964
FGF10
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.963
FGF22
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.961
FGF3
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.953
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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