C15orf39 protein (Cavia porcellus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

C15orf39

Chromosome 15 open reading frame 39. (1063 aa)

Predicted Functional Partners:

LOC100735848

0.449

LOC100712757

0.438

TP53I13

0.409

TMEM156

0.404

DSG2

0.402

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C15orf39	DSG2	ENSCPOP00000030189	ENSCPOP00000017107	Chromosome 15 open reading frame 39.	Desmoglein 2.	0.402
C15orf39	LOC100712757	ENSCPOP00000030189	ENSCPOP00000028684	Chromosome 15 open reading frame 39.	TINF2_N domain-containing protein.	0.438
C15orf39	LOC100735848	ENSCPOP00000030189	ENSCPOP00000013336	Chromosome 15 open reading frame 39.	TINF2_N domain-containing protein.	0.449
C15orf39	TMEM156	ENSCPOP00000030189	ENSCPOP00000012208	Chromosome 15 open reading frame 39.	Transmembrane protein 156.	0.404
C15orf39	TP53I13	ENSCPOP00000030189	ENSCPOP00000005146	Chromosome 15 open reading frame 39.	Tumor protein p53 inducible protein 13.	0.409
DSG2	C15orf39	ENSCPOP00000017107	ENSCPOP00000030189	Desmoglein 2.	Chromosome 15 open reading frame 39.	0.402
LOC100712757	C15orf39	ENSCPOP00000028684	ENSCPOP00000030189	TINF2_N domain-containing protein.	Chromosome 15 open reading frame 39.	0.438
LOC100712757	TMEM156	ENSCPOP00000028684	ENSCPOP00000012208	TINF2_N domain-containing protein.	Transmembrane protein 156.	0.402
LOC100712757	TP53I13	ENSCPOP00000028684	ENSCPOP00000005146	TINF2_N domain-containing protein.	Tumor protein p53 inducible protein 13.	0.515
LOC100735848	C15orf39	ENSCPOP00000013336	ENSCPOP00000030189	TINF2_N domain-containing protein.	Chromosome 15 open reading frame 39.	0.449
LOC100735848	TP53I13	ENSCPOP00000013336	ENSCPOP00000005146	TINF2_N domain-containing protein.	Tumor protein p53 inducible protein 13.	0.511
TMEM156	C15orf39	ENSCPOP00000012208	ENSCPOP00000030189	Transmembrane protein 156.	Chromosome 15 open reading frame 39.	0.404
TMEM156	LOC100712757	ENSCPOP00000012208	ENSCPOP00000028684	Transmembrane protein 156.	TINF2_N domain-containing protein.	0.402
TP53I13	C15orf39	ENSCPOP00000005146	ENSCPOP00000030189	Tumor protein p53 inducible protein 13.	Chromosome 15 open reading frame 39.	0.409
TP53I13	LOC100712757	ENSCPOP00000005146	ENSCPOP00000028684	Tumor protein p53 inducible protein 13.	TINF2_N domain-containing protein.	0.515
TP53I13	LOC100735848	ENSCPOP00000005146	ENSCPOP00000013336	Tumor protein p53 inducible protein 13.	TINF2_N domain-containing protein.	0.511

Network Stats

number of nodes:

11

number of edges:

53

average node degree:

9.64

avg. local clustering coefficient:

0.962

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090087

Regulation of peptide transport

2 of 3

2.88

1.27

0.0051

GO:0050714

Positive regulation of protein secretion

2 of 2

3.06

1.27

0.0051

GO:0046952

Ketone body catabolic process

2 of 2

3.06

1.27

0.0051

GO:0019521

D-gluconate metabolic process

2 of 4

2.76

1.26

0.0051

GO:0032787

Monocarboxylic acid metabolic process

6 of 317

1.33

1.25

0.00041

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030729

acetoacetate-CoA ligase activity

2 of 2

3.06

1.2

0.0068

GO:0008260

3-oxoacid CoA-transferase activity

2 of 2

3.06

1.2

0.0068

GO:0004616

Phosphogluconate dehydrogenase (decarboxylating) activity

2 of 2

3.06

1.2

0.0068

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12431

Valine, leucine and isoleucine degradation, and Beta oxidation of butanoyl-CoA to acetyl-CoA

4 of 32

2.15

2.24

3.76e-05

CL:14589

Pentose phosphate pathway, and Glycolytic process

4 of 44

2.02

2.15

4.12e-05

CL:14667

D-gluconate metabolic process, and Glucosamine/galactosamine-6-phosphate isomerase

2 of 5

2.66

1.5

0.0018

CL:12482

Coenzyme A transferase, and Thiolase, acyl-enzyme intermediate active site

2 of 5

2.66

1.5

0.0018

CL:14641

Pentose phosphate pathway

2 of 13

2.24

1.13

0.0078

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00650

Butanoate metabolism

4 of 35

2.12

2.65

3.99e-06

map00030

Pentose phosphate pathway

4 of 39

2.07

2.62

3.99e-06

map00280

Valine, leucine and isoleucine degradation

4 of 87

1.72

1.93

3.87e-05

map00072

Synthesis and degradation of ketone bodies

2 of 11

2.32

1.52

0.0014

map01200

Carbon metabolism

4 of 207

1.34

1.2

0.00072

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-74182

Ketone body metabolism

4 of 8

2.76

3.67

1.48e-07

MAP-77108

Utilization of Ketone Bodies

2 of 3

2.88

1.37

0.0033

MAP-77111

Synthesis of Ketone Bodies

2 of 6

2.58

1.21

0.0061

MAP-71336

Pentose phosphate pathway

2 of 22

2.02

0.72

0.0450

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0020015

Glycosome

2 of 2

3.06

1.32

0.0042

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0570

Pentose shunt

2 of 4

2.76

1.43

0.0025

KW-0521

NADP

2 of 29

1.9

0.75

0.0385

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02502

Ribose/Galactose Isomerase

2 of 2

3.06

1.31

0.0044

PF03446

NAD binding domain of 6-phosphogluconate dehydrogenase

2 of 6

2.58

1.09

0.0103

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036569

Sugar-phosphate isomerase, RpiB/LacA/LacB superfamily

2 of 2

3.06

1.05

0.0126

IPR014388

3-oxoacid CoA-transferase

2 of 2

3.06

1.05

0.0126

IPR012792

3-oxoacid CoA-transferase, subunit A

2 of 2

3.06

1.05

0.0126

IPR012791

3-oxoacid CoA-transferase, subunit B

2 of 2

3.06

1.05

0.0126

IPR011860

Ribose 5-phosphate isomerase B, Actinobacteria-type

2 of 2

3.06

1.05

0.0126

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01350

6-phosphogluconate dehydrogenase, C-terminal domain

2 of 2

3.06

1.58

0.0014

SM00882

Coenzyme A transferase

2 of 2

3.06

1.58

0.0014

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