DAPK3 protein (Cavia porcellus) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

DAPK3

Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)

Predicted Functional Partners:

MAPK1

0.918

MAPK3

0.918

LUZP1

0.845

BECN1

0.794

CALML3

0.720

CALM2

0.715

CALM1

0.715

H0VKV0_CAVPO

0.715

CALM3

0.715

ENSCPOP00000032059

0.715

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BECN1	DAPK3	ENSCPOP00000031579	ENSCPOP00000030983	Beclin 1.	Death associated protein kinase 3; Belongs to the protein kinase superfamily.	0.794
CALM1	CALML3	ENSCPOP00000002216	ENSCPOP00000012869	Calmodulin 1; Belongs to the calmodulin family.	Calmodulin like 3; Belongs to the calmodulin family.	0.618
CALM1	DAPK3	ENSCPOP00000002216	ENSCPOP00000030983	Calmodulin 1; Belongs to the calmodulin family.	Death associated protein kinase 3; Belongs to the protein kinase superfamily.	0.715
CALM1	MAPK1	ENSCPOP00000002216	ENSCPOP00000011740	Calmodulin 1; Belongs to the calmodulin family.	Mitogen-activated protein kinase.	0.405
CALM2	CALML3	ENSCPOP00000001454	ENSCPOP00000012869	Calmodulin isoform 3; Belongs to the calmodulin family.	Calmodulin like 3; Belongs to the calmodulin family.	0.850
CALM2	DAPK3	ENSCPOP00000001454	ENSCPOP00000030983	Calmodulin isoform 3; Belongs to the calmodulin family.	Death associated protein kinase 3; Belongs to the protein kinase superfamily.	0.715
CALM3	CALML3	ENSCPOP00000027832	ENSCPOP00000012869	Calmodulin 3.	Calmodulin like 3; Belongs to the calmodulin family.	0.850
CALM3	DAPK3	ENSCPOP00000027832	ENSCPOP00000030983	Calmodulin 3.	Death associated protein kinase 3; Belongs to the protein kinase superfamily.	0.715
CALM3	MAPK1	ENSCPOP00000027832	ENSCPOP00000011740	Calmodulin 3.	Mitogen-activated protein kinase.	0.446
CALML3	CALM1	ENSCPOP00000012869	ENSCPOP00000002216	Calmodulin like 3; Belongs to the calmodulin family.	Calmodulin 1; Belongs to the calmodulin family.	0.618
CALML3	CALM2	ENSCPOP00000012869	ENSCPOP00000001454	Calmodulin like 3; Belongs to the calmodulin family.	Calmodulin isoform 3; Belongs to the calmodulin family.	0.850
CALML3	CALM3	ENSCPOP00000012869	ENSCPOP00000027832	Calmodulin like 3; Belongs to the calmodulin family.	Calmodulin 3.	0.850
CALML3	DAPK3	ENSCPOP00000012869	ENSCPOP00000030983	Calmodulin like 3; Belongs to the calmodulin family.	Death associated protein kinase 3; Belongs to the protein kinase superfamily.	0.720
CALML3	ENSCPOP00000032059	ENSCPOP00000012869	ENSCPOP00000032059	Calmodulin like 3; Belongs to the calmodulin family.	Uncharacterized protein; Belongs to the calmodulin family.	0.851
CALML3	H0VKV0_CAVPO	ENSCPOP00000012869	ENSCPOP00000010954	Calmodulin like 3; Belongs to the calmodulin family.	Uncharacterized protein; Belongs to the calmodulin family.	0.851
DAPK3	BECN1	ENSCPOP00000030983	ENSCPOP00000031579	Death associated protein kinase 3; Belongs to the protein kinase superfamily.	Beclin 1.	0.794
DAPK3	CALM1	ENSCPOP00000030983	ENSCPOP00000002216	Death associated protein kinase 3; Belongs to the protein kinase superfamily.	Calmodulin 1; Belongs to the calmodulin family.	0.715
DAPK3	CALM2	ENSCPOP00000030983	ENSCPOP00000001454	Death associated protein kinase 3; Belongs to the protein kinase superfamily.	Calmodulin isoform 3; Belongs to the calmodulin family.	0.715
DAPK3	CALM3	ENSCPOP00000030983	ENSCPOP00000027832	Death associated protein kinase 3; Belongs to the protein kinase superfamily.	Calmodulin 3.	0.715
DAPK3	CALML3	ENSCPOP00000030983	ENSCPOP00000012869	Death associated protein kinase 3; Belongs to the protein kinase superfamily.	Calmodulin like 3; Belongs to the calmodulin family.	0.720

page 1 of 2

Network Stats

number of nodes:

9

number of edges:

17

average node degree:

3.78

avg. local clustering coefficient:

0.891

expected number of edges:

10

PPI enrichment p-value:

0.0217

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050650

Chondroitin sulfate proteoglycan biosynthetic process

11 of 29

2.86

13.28

2.12e-27

GO:0030206

Chondroitin sulfate biosynthetic process

9 of 23

2.87

10.77

8.09e-22

GO:0006024

Glycosaminoglycan biosynthetic process

10 of 46

2.62

10.41

1.37e-22

GO:0016051

Carbohydrate biosynthetic process

5 of 93

2.01

3.02

2.79e-07

GO:0050655

Dermatan sulfate proteoglycan metabolic process

3 of 8

2.85

2.89

5.06e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0047238

glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

5 of 7

3.13

5.98

9.98e-12

GO:0015020

Glucuronosyltransferase activity

6 of 30

2.58

5.61

9.98e-12

GO:0008376

Acetylgalactosaminyltransferase activity

6 of 37

2.49

5.41

1.56e-11

GO:0008194

UDP-glycosyltransferase activity

8 of 164

1.97

4.46

7.37e-12

GO:0016758

Hexosyltransferase activity

8 of 219

1.84

4.0

1.56e-11

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032580

Golgi cisterna membrane

6 of 64

2.25

4.52

3.14e-10

GO:0005794

Golgi apparatus

11 of 1150

1.26

2.05

1.76e-11

GO:0000139

Golgi membrane

5 of 435

1.34

1.3

0.00026

GO:0031090

Organelle membrane

11 of 2746

0.88

0.99

4.90e-08

GO:0016021

Integral component of membrane

10 of 5384

0.55

0.44

0.0013

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:37052

Signal-anchor

11 of 26

2.91

13.75

4.25e-28

CL:37055

Signal-anchor

10 of 20

2.98

12.84

1.04e-25

CL:37057

glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity, and Glycosyltransferase family 43

7 of 14

2.98

8.52

7.78e-17

CL:37060

Chondroitin N-acetylgalactosaminyltransferase

3 of 5

3.06

2.98

3.72e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00532

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

9 of 30

2.76

10.46

1.03e-21

map01100

Metabolic pathways

8 of 3033

0.7

0.55

0.0020

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1793185

Chondroitin sulfate/dermatan sulfate metabolism

10 of 77

2.39

8.76

1.58e-20

MAP-2022870

Chondroitin sulfate biosynthesis

8 of 33

2.67

8.4

1.39e-17

MAP-1630316

Glycosaminoglycan metabolism

10 of 175

2.04

6.24

1.39e-17

MAP-71387

Metabolism of carbohydrates

10 of 355

1.73

4.22

9.99e-15

MAP-1430728

Metabolism

10 of 2615

0.86

0.89

2.97e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032580

Golgi cisterna membrane

4 of 18

2.63

3.62

1.51e-07

GOCC:0000139

Golgi membrane

6 of 155

1.87

3.05

6.30e-08

GOCC:0005794

Golgi apparatus

8 of 510

1.48

2.3

3.05e-08

GOCC:0043231

Intracellular membrane-bounded organelle

10 of 5979

0.5

0.38

0.0044

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0735

Signal-anchor

10 of 35

2.74

11.54

2.44e-24

KW-0333

Golgi apparatus

10 of 135

2.15

7.23

3.13e-19

KW-0119

Carbohydrate metabolism

3 of 35

2.21

2.14

7.14e-05

KW-0325

Glycoprotein

3 of 56

2.01

1.87

0.00018

KW-0808

Transferase

10 of 1665

1.06

1.36

1.10e-08

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02709

N-terminal domain of galactosyltransferase

4 of 16

2.68

3.39

4.49e-07

PF03567

Sulfotransferase family

3 of 21

2.44

1.93

0.00025

PF05679

Chondroitin N-acetylgalactosaminyltransferase

2 of 4

2.98

1.41

0.0028

PF03360

Glycosyltransferase family 43

2 of 4

2.98

1.41

0.0028

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008428

Chondroitin N-acetylgalactosaminyltransferase

5 of 8

3.08

5.39

1.18e-10

IPR029044

Nucleotide-diphospho-sugar transferases

7 of 96

2.14

4.49

1.18e-10

IPR018011

Carbohydrate sulfotransferase 8-10

3 of 11

2.72

2.21

8.76e-05

IPR005331

Sulfotransferase

3 of 18

2.5

1.95

0.00024

IPR005027

Glycosyl transferase, family 43

2 of 4

2.98

1.27

0.0051

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