STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLXNA2Plexin A2. (1894 aa)    
Predicted Functional Partners:
NRP1
Neuropilin; Belongs to the neuropilin family.
    
 0.998
SEMA6A
Semaphorin 6A; Belongs to the semaphorin family.
    
0.993
RND1
Rho family GTPase 1.
    
 0.990
SEMA3A
Semaphorin 3A; Belongs to the semaphorin family.
    
 0.979
RAC2
Ras-related C3 botulinum toxin substrate 2; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase (By similarity).
   
 0.945
RHOD
Ras homolog family member D.
    
 0.945
FYN
Tyrosine-protein kinase.
    
 0.922
PLXNA1
Plexin A1.
  
  
0.916
PLXNA4
Plexin A4.
  
  
0.910
RAC1
Ras-related C3 botulinum toxin substrate 1.
   
 0.894
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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