HIC2 protein (Cavia porcellus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

HIC2

HIC ZBTB transcriptional repressor 2. (618 aa)

Predicted Functional Partners:

SIRT1

0.614

UBE2I

0.608

CTBP1

0.592

KCTD2

0.590

SUMO1

0.580

MPP5

0.556

BARD1

0.506

CTBP2

0.496

NME8

0.466

PIAS1

0.462

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARD1	CTBP1	ENSCPOP00000010340	ENSCPOP00000017468	BRCA1 associated RING domain 1.	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.443
BARD1	CTBP2	ENSCPOP00000010340	ENSCPOP00000032434	BRCA1 associated RING domain 1.	C-terminal binding protein 2.	0.443
BARD1	HIC2	ENSCPOP00000010340	ENSCPOP00000031817	BRCA1 associated RING domain 1.	HIC ZBTB transcriptional repressor 2.	0.506
BARD1	KCTD2	ENSCPOP00000010340	ENSCPOP00000014814	BRCA1 associated RING domain 1.	Potassium channel tetramerization domain containing 2.	0.848
BARD1	PIAS1	ENSCPOP00000010340	ENSCPOP00000006557	BRCA1 associated RING domain 1.	Protein inhibitor of activated STAT 1.	0.732
BARD1	SUMO1	ENSCPOP00000010340	ENSCPOP00000027854	BRCA1 associated RING domain 1.	Small ubiquitin-related modifier.	0.660
BARD1	UBE2I	ENSCPOP00000010340	ENSCPOP00000030951	BRCA1 associated RING domain 1.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.848
CTBP1	BARD1	ENSCPOP00000017468	ENSCPOP00000010340	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	BRCA1 associated RING domain 1.	0.443
CTBP1	CTBP2	ENSCPOP00000017468	ENSCPOP00000032434	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	C-terminal binding protein 2.	0.989
CTBP1	HIC2	ENSCPOP00000017468	ENSCPOP00000031817	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	HIC ZBTB transcriptional repressor 2.	0.592
CTBP1	KCTD2	ENSCPOP00000017468	ENSCPOP00000014814	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Potassium channel tetramerization domain containing 2.	0.582
CTBP1	SUMO1	ENSCPOP00000017468	ENSCPOP00000027854	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Small ubiquitin-related modifier.	0.471
CTBP1	UBE2I	ENSCPOP00000017468	ENSCPOP00000030951	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.671
CTBP2	BARD1	ENSCPOP00000032434	ENSCPOP00000010340	C-terminal binding protein 2.	BRCA1 associated RING domain 1.	0.443
CTBP2	CTBP1	ENSCPOP00000032434	ENSCPOP00000017468	C-terminal binding protein 2.	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.989
CTBP2	HIC2	ENSCPOP00000032434	ENSCPOP00000031817	C-terminal binding protein 2.	HIC ZBTB transcriptional repressor 2.	0.496
CTBP2	KCTD2	ENSCPOP00000032434	ENSCPOP00000014814	C-terminal binding protein 2.	Potassium channel tetramerization domain containing 2.	0.582
CTBP2	SUMO1	ENSCPOP00000032434	ENSCPOP00000027854	C-terminal binding protein 2.	Small ubiquitin-related modifier.	0.471
CTBP2	UBE2I	ENSCPOP00000032434	ENSCPOP00000030951	C-terminal binding protein 2.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.662
HIC2	BARD1	ENSCPOP00000031817	ENSCPOP00000010340	HIC ZBTB transcriptional repressor 2.	BRCA1 associated RING domain 1.	0.506