STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Fcgr4Low affinity immunoglobulin gamma Fc region receptor IV; Receptor for the Fc region of immunoglobulin gamma. Also acts as a receptor for the Fc region of immunoglobulin epsilon (By similarity). Binds with intermediate affinity to both IgG2a and IgG2b (By similarity). Can bind to IgG2a and IgG2b monomers (By similarity). Does not display binding to IgG1 or IgG3 (By similarity). Mediates neutrophil activation by IgG complexes redundantly with Fcgr3 (By similarity). Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (By similarity) [...] (250 aa)    
Predicted Functional Partners:
H0V0F4_CAVPO
Uncharacterized protein.
   
 0.984
FCER1G
High affinity immunoglobulin epsilon receptor subunit gamma; Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functi [...]
   
 
 0.934
ENSCPOP00000022635
Uncharacterized protein.
   
 0.912
CD247
CD247 molecule.
     
 0.886
LOC100718571
Ig-like domain-containing protein.
   
 0.879
SYK
Tyrosine-protein kinase.
   
 0.872
FCGR2
Low affinity immunoglobulin gamma Fc region receptor II; Binds to the Fc region of immunoglobulins gamma. Low affinity receptor.
   
 
0.850
LYN
Tyrosine-protein kinase.
   
 0.823
Sirpa
Ig-like domain-containing protein.
   
 0.819
LOC100719905
Uncharacterized protein.
   
 0.817
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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